BDBM4850 1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[2,3-d]pyrimidin-7-yl}-3-tert-butylurea::CHEMBL50371::PD089828 analog 31

SMILES: CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C

InChI Key: InChIKey=VUMSJQHDUMFUHU-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 4850   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4850 (1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...) Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4850 (1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...) Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM4850 (1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...) Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description Inhibitory activity against platelet-derived growth factor receptor				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha (Mus musculus (mouse))	BDBM4850 (1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...) Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)	MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor				J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken))	BDBM4850 (1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...) Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of chicken c-Src tyrosine kinase				J Med Chem 41: 1752-63 (1998) Article DOI: 10.1021/jm970634p BindingDB Entry DOI: 10.7270/Q26T0KQ6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4850 (1-{2-amino-6-[3,5-bis(dimethylamino)phenyl]pyrido[...) Show SMILES CN(C)c1cc(cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C)N(C)C Show InChI InChI=1S/C22H30N8O/c1-22(2,3)28-21(31)27-19-17(10-14-12-24-20(23)26-18(14)25-19)13-8-15(29(4)5)11-16(9-13)30(6)7/h8-12H,1-7H3,(H4,23,24,25,26,27,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...				Bioorg Med Chem Lett 7: 2415-20 (1997) Article DOI: 10.1074/jbc.M606873200 BindingDB Entry DOI: 10.7270/Q28C9TF2
					More data for this Ligand-Target Pair