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BDBM4855 1-(4-Chloroanilino)-4-(3-pyridylmethyl)phthalazine Hydrochloride::CGP79787 Analog 40::N-(4-chlorophenyl)-4-(pyridin-3-ylmethyl)phthalazin-1-amine

SMILES: Clc1ccc(Nc2nnc(Cc3cccnc3)c3ccccc23)cc1

InChI Key: InChIKey=GNNTUYLPJHMKJZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4855   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4855
PNG
(1-(4-Chloroanilino)-4-(3-pyridylmethyl)phthalazine...)
Show SMILES Clc1ccc(Nc2nnc(Cc3cccnc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-7-9-16(10-8-15)23-20-18-6-2-1-5-17(18)19(24-25-20)12-14-4-3-11-22-13-14/h1-11,13H,12H2,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...


J Med Chem 43: 2310-23 (2000)


Article DOI: 10.1021/jm060561m
BindingDB Entry DOI: 10.7270/Q24M92R5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM4855
PNG
(1-(4-Chloroanilino)-4-(3-pyridylmethyl)phthalazine...)
Show SMILES Clc1ccc(Nc2nnc(Cc3cccnc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-7-9-16(10-8-15)23-20-18-6-2-1-5-17(18)19(24-25-20)12-14-4-3-11-22-13-14/h1-11,13H,12H2,(H,23,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 9.80E+3n/an/an/an/a7.522



Novartis Pharmaceuticals



Assay Description
The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...


J Med Chem 43: 2310-23 (2000)


Article DOI: 10.1021/jm060561m
BindingDB Entry DOI: 10.7270/Q24M92R5
More data for this
Ligand-Target Pair