BDBM4863 1-(4-Chloroanilino)-4-(4-pyridylmethyl)-6-methylphthalazine and 1-(4-Chloroanilino)-4-(4-pyridylmethyl)-7-methylphthalazine Dihydrochloride::CGP79787 Analog 46::N-(4-chlorophenyl)-7-methyl-4-(pyridin-4-ylmethyl)phthalazin-1-amine

SMILES: Cc1ccc2c(Cc3ccncc3)nnc(Nc3ccc(Cl)cc3)c2c1

InChI Key: InChIKey=YVMDSPWVEDPXJR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4863   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4863 (1-(4-Chloroanilino)-4-(4-pyridylmethyl)-6-methylph...) Show SMILES Cc1ccc2c(Cc3ccncc3)nnc(Nc3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C21H17ClN4/c1-14-2-7-18-19(12-14)21(24-17-5-3-16(22)4-6-17)26-25-20(18)13-15-8-10-23-11-9-15/h2-12H,13H2,1H3,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharmaceuticals					Assay Description The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...				J Med Chem 43: 2310-23 (2000) Article DOI: 10.1021/jm9909443 BindingDB Entry DOI: 10.7270/Q24M92R5
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM4863 (1-(4-Chloroanilino)-4-(4-pyridylmethyl)-6-methylph...) Show SMILES Cc1ccc2c(Cc3ccncc3)nnc(Nc3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C21H17ClN4/c1-14-2-7-18-19(12-14)21(24-17-5-3-16(22)4-6-17)26-25-20(18)13-15-8-10-23-11-9-15/h2-12H,13H2,1H3,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis Pharmaceuticals					Assay Description The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...				J Med Chem 43: 2310-23 (2000) Article DOI: 10.1021/jm9909443 BindingDB Entry DOI: 10.7270/Q24M92R5
					More data for this Ligand-Target Pair