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BDBM4874 1-(3-Methoxyanilino)-4-(4-pyridylmethyl)phthalazine::CGP79787 Analog 59::N-(3-methoxyphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

SMILES: COc1cccc(Nc2nnc(Cc3ccncc3)c3ccccc23)c1

InChI Key: InChIKey=UHSUYVQDJJMDAA-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4874   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM4874
PNG
(1-(3-Methoxyanilino)-4-(4-pyridylmethyl)phthalazin...)
Show SMILES COc1cccc(Nc2nnc(Cc3ccncc3)c3ccccc23)c1
Show InChI InChI=1S/C21H18N4O/c1-26-17-6-4-5-16(14-17)23-21-19-8-3-2-7-18(19)20(24-25-21)13-15-9-11-22-12-10-15/h2-12,14H,13H2,1H3,(H,23,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...


J Med Chem 43: 2310-23 (2000)


Article DOI: 10.1021/jm060561m
BindingDB Entry DOI: 10.7270/Q24M92R5
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM4874
PNG
(1-(3-Methoxyanilino)-4-(4-pyridylmethyl)phthalazin...)
Show SMILES COc1cccc(Nc2nnc(Cc3ccncc3)c3ccccc23)c1
Show InChI InChI=1S/C21H18N4O/c1-26-17-6-4-5-16(14-17)23-21-19-8-3-2-7-18(19)20(24-25-21)13-15-9-11-22-12-10-15/h2-12,14H,13H2,1H3,(H,23,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...


J Med Chem 43: 2310-23 (2000)


Article DOI: 10.1021/jm060561m
BindingDB Entry DOI: 10.7270/Q24M92R5
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4874
PNG
(1-(3-Methoxyanilino)-4-(4-pyridylmethyl)phthalazin...)
Show SMILES COc1cccc(Nc2nnc(Cc3ccncc3)c3ccccc23)c1
Show InChI InChI=1S/C21H18N4O/c1-26-17-6-4-5-16(14-17)23-21-19-8-3-2-7-18(19)20(24-25-21)13-15-9-11-22-12-10-15/h2-12,14H,13H2,1H3,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The autophosphorylation assay was performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified ov...


J Med Chem 43: 2310-23 (2000)


Article DOI: 10.1021/jm060561m
BindingDB Entry DOI: 10.7270/Q24M92R5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM4874
PNG
(1-(3-Methoxyanilino)-4-(4-pyridylmethyl)phthalazin...)
Show SMILES COc1cccc(Nc2nnc(Cc3ccncc3)c3ccccc23)c1
Show InChI InChI=1S/C21H18N4O/c1-26-17-6-4-5-16(14-17)23-21-19-8-3-2-7-18(19)20(24-25-21)13-15-9-11-22-12-10-15/h2-12,14H,13H2,1H3,(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...


J Med Chem 43: 2310-23 (2000)


Article DOI: 10.1021/jm060561m
BindingDB Entry DOI: 10.7270/Q24M92R5
More data for this
Ligand-Target Pair