BDBM4902 3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid::3-substituted indolin-2-one 16h

SMILES: COc1ccccc1-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1

InChI Key: InChIKey=MPBRWFJYTOVGPY-MOSHPQCFSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4902   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM4902 (3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-...) Show SMILES COc1ccccc1-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1 Show InChI InChI=1S/C25H24N2O4/c1-14-17(10-11-24(28)29)15(2)26-21(14)13-20-19-9-8-16(12-22(19)27-25(20)30)18-6-4-5-7-23(18)31-3/h4-9,12-13,26H,10-11H2,1-3H3,(H,27,30)(H,28,29)/b20-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4902 (3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-...) Show SMILES COc1ccccc1-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1 Show InChI InChI=1S/C25H24N2O4/c1-14-17(10-11-24(28)29)15(2)26-21(14)13-20-19-9-8-16(12-22(19)27-25(20)30)18-6-4-5-7-23(18)31-3/h4-9,12-13,26H,10-11H2,1-3H3,(H,27,30)(H,28,29)/b20-13-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4902 (3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-...) Show SMILES COc1ccccc1-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1 Show InChI InChI=1S/C25H24N2O4/c1-14-17(10-11-24(28)29)15(2)26-21(14)13-20-19-9-8-16(12-22(19)27-25(20)30)18-6-4-5-7-23(18)31-3/h4-9,12-13,26H,10-11H2,1-3H3,(H,27,30)(H,28,29)/b20-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4902 (3-(5-{[(3Z)-6-(2-methoxyphenyl)-2-oxo-2,3-dihydro-...) Show SMILES COc1ccccc1-c1ccc2\C(=C\c3[nH]c(C)c(CCC(O)=O)c3C)C(=O)Nc2c1 Show InChI InChI=1S/C25H24N2O4/c1-14-17(10-11-24(28)29)15(2)26-21(14)13-20-19-9-8-16(12-22(19)27-25(20)30)18-6-4-5-7-23(18)31-3/h4-9,12-13,26H,10-11H2,1-3H3,(H,27,30)(H,28,29)/b20-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
					More data for this Ligand-Target Pair