Found 6 hits for monomerid = 50000317 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000317
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of TXA2 synthetase from human platelets |
J Med Chem 29: 342-6 (1986)
BindingDB Entry DOI: 10.7270/Q2W66JSZ |
More data for this Ligand-Target Pair | |
Prostaglandin I2 synthase
(Homo sapiens (Human)) | BDBM50000317
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of PGI-2 synthetase from porcine aorta |
J Med Chem 29: 342-6 (1986)
BindingDB Entry DOI: 10.7270/Q2W66JSZ |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50000317
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Prostaglandin G/H synthase from ram seminal vesicle microsomes |
J Med Chem 29: 342-6 (1986)
BindingDB Entry DOI: 10.7270/Q2W66JSZ |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000317
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description Activity against human platelet microsome Thromboxane synthase |
J Med Chem 40: 3442-52 (1997)
Article DOI: 10.1021/jm9702793 BindingDB Entry DOI: 10.7270/Q2Z0378X |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50000317
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human platelet microsomal TXA2 synthase |
Bioorg Med Chem Lett 6: 1691-1696 (1996)
Article DOI: 10.1016/0960-894X(96)00299-5 BindingDB Entry DOI: 10.7270/Q27P8ZBS |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B1
(Rattus norvegicus) | BDBM50000317
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of 11 beta-hydroxylase from rat adrenal gland |
J Med Chem 29: 342-6 (1986)
BindingDB Entry DOI: 10.7270/Q2W66JSZ |
More data for this Ligand-Target Pair | |