BDBM50000345 1-(2-Dimethylamino-propyl)-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one::CHEMBL349753

SMILES: COc1ccc(cc1)[C@@H]1Cc2c(cccc2C(F)(F)F)N(CC(C)N(C)C)C(=O)[C@@H]1C

InChI Key: InChIKey=QJKYHGAXHUSJEM-HFLHWUEFSA-N

Data: 1 Kd

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50000345   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated L-type calcium channel (Homo sapiens (Human))	BDBM50000345 (1-(2-Dimethylamino-propyl)-4-(4-methoxy-phenyl)-3-...) Show SMILES COc1ccc(cc1)[C@@H]1Cc2c(cccc2C(F)(F)F)N(CC(C)N(C)C)C(=O)[C@@H]1C Show InChI InChI=1S/C24H29F3N2O2/c1-15(28(3)4)14-29-22-8-6-7-21(24(25,26)27)20(22)13-19(16(2)23(29)30)17-9-11-18(31-5)12-10-17/h6-12,15-16,19H,13-14H2,1-5H3/t15?,16-,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro ability to displace the specific binding of [3H]-diltiazem to diltiazem receptor in guinea pig skeletal muscle.				J Med Chem 35: 780-93 (1992) BindingDB Entry DOI: 10.7270/Q2K64H14
					More data for this Ligand-Target Pair