BDBM50000359 1-(2-Dimethylamino-1-methyl-ethyl)-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one::CHEMBL167987
SMILES: COc1ccc(cc1)[C@@H]1Cc2c(cccc2C(F)(F)F)N(C(C)CN(C)C)C(=O)[C@@H]1C
InChI Key: InChIKey=KLLFPPGWPOQJKZ-HFLHWUEFSA-N
Data: 2 Kd
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-gated calcium channel (Homo sapiens (Human)) | BDBM50000359 (1-(2-Dimethylamino-1-methyl-ethyl)-4-(4-methoxy-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro ability to displace the specific binding of [3H]-diltiazem to diltiazem receptor in guinea pig skeletal muscle. | J Med Chem 35: 780-93 (1992) BindingDB Entry DOI: 10.7270/Q2K64H14 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-gated L-type calcium channel (Homo sapiens (Human)) | BDBM50000359 (1-(2-Dimethylamino-1-methyl-ethyl)-4-(4-methoxy-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro ability to displace the specific binding of [3H]-diltiazem to diltiazem receptor in guinea pig skeletal muscle. | J Med Chem 35: 780-93 (1992) BindingDB Entry DOI: 10.7270/Q2K64H14 | |||||||||||
More data for this Ligand-Target Pair |