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BDBM50000379 1-[2-(Isopropyl-methyl-amino)-ethyl]-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one::CHEMBL353566

SMILES: COc1ccc(cc1)[C@@H]1Cc2c(cccc2C(F)(F)F)N(CCN(C)C(C)C)C(=O)[C@@H]1C

InChI Key: InChIKey=GBZUXDPXMPXSQT-YLJYHZDGSA-N

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50000379   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-gated L-type calcium channel


(Homo sapiens (Human))		BDBM50000379
PNG
(1-[2-(Isopropyl-methyl-amino)-ethyl]-4-(4-methoxy-...)
Show SMILES COc1ccc(cc1)[C@@H]1Cc2c(cccc2C(F)(F)F)N(CCN(C)C(C)C)C(=O)[C@@H]1C
Show InChI InChI=1S/C25H31F3N2O2/c1-16(2)29(4)13-14-30-23-8-6-7-22(25(26,27)28)21(23)15-20(17(3)24(30)31)18-9-11-19(32-5)12-10-18/h6-12,16-17,20H,13-15H2,1-5H3/t17-,20-/m1/s1
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PubMed
n/an/an/a 130n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro ability to displace the specific binding of [3H]-diltiazem to diltiazem receptor in guinea pig skeletal muscle.

J Med Chem 35: 780-93 (1992)


BindingDB Entry DOI: 10.7270/Q2K64H14
More data for this
Ligand-Target Pair