BDBM50000832 2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-ethyl}-thiazole::CHEMBL70191

SMILES: COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1

InChI Key: InChIKey=OXJFHHZLINJDQD-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50000832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for the inhibition of 5-lipoxygenase (5-Lpo) in guinea pig.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in mouse macrophages.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for the inhibition of 5-lipoxygenase (5-Lpo) in rat whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibition of leukotriene B4 synthesis in human whole blood by inhibiting 5-lipoxygenase				J Med Chem 35: 2600-9 (1992) BindingDB Entry DOI: 10.7270/Q2Q240VJ
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Compound was tested for the inhibition of 5-lipoxygenase (5-Lpo) in guinea pig.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in mouse macrophages.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Mus musculus)	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in mouse macrophages.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50000832 (2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...) Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human whole blood.				J Med Chem 34: 2176-86 (1991) BindingDB Entry DOI: 10.7270/Q2S46QX6
					More data for this Ligand-Target Pair