BDBM50000870 7-(3-Benzenesulfonyl-propoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one::CHEMBL90677

SMILES: O=c1[nH]c2cc3cc(OCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1

InChI Key: InChIKey=CXKZVQGXPZXMLT-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50000870   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50000870 (7-(3-Benzenesulfonyl-propoxy)-1,3-dihydro-imidazo[...) Show SMILES O=c1[nH]c2cc3cc(OCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1 Show InChI InChI=1S/C19H17N3O4S/c23-19-21-17-12-13-11-14(7-8-16(13)20-18(17)22-19)26-9-4-10-27(24,25)15-5-2-1-3-6-15/h1-3,5-8,11-12H,4,9-10H2,(H2,20,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase A/B (Homo sapiens (Human))	BDBM50000870 (7-(3-Benzenesulfonyl-propoxy)-1,3-dihydro-imidazo[...) Show SMILES O=c1[nH]c2cc3cc(OCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1 Show InChI InChI=1S/C19H17N3O4S/c23-19-21-17-12-13-11-14(7-8-16(13)20-18(17)22-19)26-9-4-10-27(24,25)15-5-2-1-3-6-15/h1-3,5-8,11-12H,4,9-10H2,(H2,20,21,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
P2Y purinoceptor 12 (Homo sapiens (Human))	BDBM50000870 (7-(3-Benzenesulfonyl-propoxy)-1,3-dihydro-imidazo[...) Show SMILES O=c1[nH]c2cc3cc(OCCCS(=O)(=O)c4ccccc4)ccc3nc2[nH]1 Show InChI InChI=1S/C19H17N3O4S/c23-19-21-17-12-13-11-14(7-8-16(13)20-18(17)22-19)26-9-4-10-27(24,25)15-5-2-1-3-6-15/h1-3,5-8,11-12H,4,9-10H2,(H2,20,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair