BDBM50000875 1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyryl]-piperidine-4-carboxylic acid ethyl ester::CHEMBL328149

SMILES: CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1

InChI Key: InChIKey=FYTROBAKOHFNCC-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50000875   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50000875 (1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...) Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
Purinergic receptor P2Y12 (Homo sapiens (Human))	BDBM50000875 (1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...) Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50000875 (1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...) Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair
Purinergic receptor P2Y12 (Homo sapiens (Human))	BDBM50000875 (1-[4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-...) Show SMILES CCOC(=O)C1CCN(CC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1 Show InChI InChI=1S/C22H26N4O5/c1-2-30-21(28)14-7-9-26(10-8-14)19(27)4-3-11-31-16-5-6-17-15(12-16)13-18-20(23-17)25-22(29)24-18/h5-6,12-14H,2-4,7-11H2,1H3,(H2,23,24,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)				J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52
					More data for this Ligand-Target Pair