BDBM50000931 CHEMBL91368::N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide(HCl)
SMILES: CN(C1CCCCC1)C(=O)CCCOc1ccc2nc3[nH]c(=O)[nH]c3cc2c1
InChI Key: InChIKey=RBJPQMVNZAIYKC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50000931 (CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y12 (Homo sapiens (Human)) | BDBM50000931 (CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purinergic receptor P2Y12 (Homo sapiens (Human)) | BDBM50000931 (CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50000931 (CHEMBL91368 | N-Cyclohexyl-N-methyl-4-(2-oxo-2,3-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis | J Med Chem 35: 2672-87 (1992) BindingDB Entry DOI: 10.7270/Q2513X52 | |||||||||||
More data for this Ligand-Target Pair |