null
SMILES: OC(=O)c1cccc(NCc2cccc(c2)-n2ccc3c(cccc23)-c2ccc(cc2)C(F)(F)F)c1
InChI Key: InChIKey=XPJOGIGKCTXMJB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EHMT2 (Homo sapiens (Human)) | BDBM50001750 (CHEMBL3238424) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rockefeller University Curated by ChEMBL | Assay Description Inhibition of C-terminal GST-tagged human G9a-mediated-methylation of histone3 expressed in Escherichia coli BL21(DE3) by MALDI-TOF mass spectrometry | Bioorg Med Chem 22: 2253-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.024 BindingDB Entry DOI: 10.7270/Q2FB54FG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SETD7 (Homo sapiens (Human)) | BDBM50001750 (CHEMBL3238424) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rockefeller University Curated by ChEMBL | Assay Description Inhibition of SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin after 5 mins by scintillation proximity assay in presence of [... | Bioorg Med Chem 22: 2253-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.024 BindingDB Entry DOI: 10.7270/Q2FB54FG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SETD7 (Homo sapiens (Human)) | BDBM50001750 (CHEMBL3238424) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rockefeller University Curated by ChEMBL | Assay Description Inhibition of 100 nM SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin at 15 to 50 uM after 5 mins by scintillation proximity ... | Bioorg Med Chem 22: 2253-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.024 BindingDB Entry DOI: 10.7270/Q2FB54FG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SETD7 (Homo sapiens (Human)) | BDBM50001750 (CHEMBL3238424) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rockefeller University Curated by ChEMBL | Assay Description Inhibition of 10 nM SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin at 15 to 50 uM after 5 mins by scintillation proximity a... | Bioorg Med Chem 22: 2253-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.024 BindingDB Entry DOI: 10.7270/Q2FB54FG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SETD7 (Homo sapiens (Human)) | BDBM50001750 (CHEMBL3238424) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rockefeller University Curated by ChEMBL | Assay Description Inhibition of 50 nM SET7 (unknown origin)-mediated methylation of histone H3(1-20)cys-biotin at 15 to 50 uM after 5 mins by scintillation proximity a... | Bioorg Med Chem 22: 2253-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.024 BindingDB Entry DOI: 10.7270/Q2FB54FG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SETD7 (Homo sapiens (Human)) | BDBM50001750 (CHEMBL3238424) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rockefeller University Curated by ChEMBL | Assay Description Inhibition of methyl-transferase activity in GST-tagged recombinant SET7/9 (unknown origin) expressed in Escherichia coli BL21 using H3(1-20)-cys-bio... | Bioorg Med Chem 22: 2253-60 (2014) Article DOI: 10.1016/j.bmc.2014.02.024 BindingDB Entry DOI: 10.7270/Q2FB54FG | |||||||||||
More data for this Ligand-Target Pair |