BDBM50001772 1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one::CHEMBL423009
SMILES: Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2ccc(Cl)cc12
InChI Key: InChIKey=KAVXLKNTCZXGHC-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50001772 (1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes | J Med Chem 35: 4813-22 (1993) BindingDB Entry DOI: 10.7270/Q2G73CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50001772 (1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of whole rat brain membranes | J Med Chem 35: 4813-22 (1993) BindingDB Entry DOI: 10.7270/Q2G73CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50001772 (1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor from rat cortical membranes. | J Med Chem 35: 4813-22 (1993) BindingDB Entry DOI: 10.7270/Q2G73CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50001772 (1-(2-{4-[6-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S Curated by ChEMBL | Assay Description Binding affinity at dopamine D2 receptor by [3H]-Spiperone displacement. | J Med Chem 37: 950-62 (1994) BindingDB Entry DOI: 10.7270/Q2GF0SKK | |||||||||||
More data for this Ligand-Target Pair |