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BDBM50002086 11-(3-Pyrrolidin-1-yl-propylidene)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid; compound with but-2-enedioic acid::CHEMBL304223

SMILES: OC(=O)c1ccc2OCc3ccccc3\C(=C\CCN3CCCC3)c2c1

InChI Key: InChIKey=PXSGFJRZQDHJSY-UWVJOHFNSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50002086   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50002086
PNG
(11-(3-Pyrrolidin-1-yl-propylidene)-6,11-dihydro-di...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3\C(=C\CCN3CCCC3)c2c1
Show InChI InChI=1S/C22H23NO3/c24-22(25)16-9-10-21-20(14-16)19(8-5-13-23-11-3-4-12-23)18-7-2-1-6-17(18)15-26-21/h1-2,6-10,14H,3-5,11-13,15H2,(H,24,25)/b19-8-
UniProtKB/SwissProt

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PC sid
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Similars
PubMed
 5n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM

J Med Chem 35: 2074-84 (1992)


BindingDB Entry DOI: 10.7270/Q2N87BC0
More data for this
Ligand-Target Pair