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BDBM50002098 11-(4-Dimethylamino-butylidene)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid::CHEMBL304042

SMILES: CN(C)CCC\C=C1/c2ccccc2COc2ccc(cc12)C(O)=O

InChI Key: InChIKey=ARFFJDYERFVHNC-GIJQJNRQSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50002098   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50002098
PNG
(11-(4-Dimethylamino-butylidene)-6,11-dihydro-diben...)
Show SMILES CN(C)CCC\C=C1/c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C21H23NO3/c1-22(2)12-6-5-9-18-17-8-4-3-7-16(17)14-25-20-11-10-15(21(23)24)13-19(18)20/h3-4,7-11,13H,5-6,12,14H2,1-2H3,(H,23,24)/b18-9+
UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
PubMed
 6.30n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM

J Med Chem 35: 2074-84 (1992)


BindingDB Entry DOI: 10.7270/Q2N87BC0
More data for this
Ligand-Target Pair