Found 5 hits for monomerid = 50002594 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002594
(CHEMBL2113186)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccc(cc4)-n4ccnc4)=CC3=O)c2cc1OC |c:31,t:13| Show InChI InChI=1S/C27H23N5O6/c1-35-9-10-37-26-13-20-19(11-25(26)36-2)27(30-15-29-20)31-21-12-23(34)24(14-22(21)33)38-18-5-3-17(4-6-18)32-8-7-28-16-32/h3-8,11-16H,9-10H2,1-2H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002594
(CHEMBL2113186)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccc(cc4)-n4ccnc4)=CC3=O)c2cc1OC |c:31,t:13| Show InChI InChI=1S/C27H23N5O6/c1-35-9-10-37-26-13-20-19(11-25(26)36-2)27(30-15-29-20)31-21-12-23(34)24(14-22(21)33)38-18-5-3-17(4-6-18)32-8-7-28-16-32/h3-8,11-16H,9-10H2,1-2H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002594
(CHEMBL2113186)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccc(cc4)-n4ccnc4)=CC3=O)c2cc1OC |c:31,t:13| Show InChI InChI=1S/C27H23N5O6/c1-35-9-10-37-26-13-20-19(11-25(26)36-2)27(30-15-29-20)31-21-12-23(34)24(14-22(21)33)38-18-5-3-17(4-6-18)32-8-7-28-16-32/h3-8,11-16H,9-10H2,1-2H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002594
(CHEMBL2113186)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccc(cc4)-n4ccnc4)=CC3=O)c2cc1OC |c:31,t:13| Show InChI InChI=1S/C27H23N5O6/c1-35-9-10-37-26-13-20-19(11-25(26)36-2)27(30-15-29-20)31-21-12-23(34)24(14-22(21)33)38-18-5-3-17(4-6-18)32-8-7-28-16-32/h3-8,11-16H,9-10H2,1-2H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50002594
(CHEMBL2113186)Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(Oc4ccc(cc4)-n4ccnc4)=CC3=O)c2cc1OC |c:31,t:13| Show InChI InChI=1S/C27H23N5O6/c1-35-9-10-37-26-13-20-19(11-25(26)36-2)27(30-15-29-20)31-21-12-23(34)24(14-22(21)33)38-18-5-3-17(4-6-18)32-8-7-28-16-32/h3-8,11-16H,9-10H2,1-2H3,(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP |
J Med Chem 48: 7560-81 (2005)
Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S |
More data for this Ligand-Target Pair | |