BDBM50002805 (daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phenyl}-acetic acid::BM 13505::BM-13505::CHEMBL71685::Daltroban::{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phenyl}-acetic acid
SMILES: OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1
InChI Key: InChIKey=IULOBWFWYDMECP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50002805 ((daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-e...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents | PubMed | 5.43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Squibb Institute for Medical Research Curated by PDSP Ki Database | J Pharmacol Exp Ther 245: 786-92 (1988) BindingDB Entry DOI: 10.7270/Q2D21W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50002805 ((daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-e...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents | PubMed | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Squibb Institute for Medical Research Curated by PDSP Ki Database | J Pharmacol Exp Ther 245: 786-92 (1988) BindingDB Entry DOI: 10.7270/Q2D21W4Z | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50002805 ((daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-e...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents | PubMed | 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Company, Ltd. Curated by ChEMBL | Assay Description Compound was tested for its binding affinity at Thromboxane A2/ Prostaglandin H2 receptor by measuring its ability to displace [3H]-U-46,619 from gui... | J Med Chem 35: 3402-13 (1992) BindingDB Entry DOI: 10.7270/Q2J38RG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane A2 receptor (RAT) | BDBM50002805 ((daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-e...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents | PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Zeria Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description In vitro thromboxane A2 antagonistic activity of the compound on U-46619 (0.1 uM) induced contraction of rat aorta | Bioorg Med Chem Lett 9: 401-6 (1999) BindingDB Entry DOI: 10.7270/Q2GB2363 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Rattus norvegicus) | BDBM50002805 ((daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-e...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia-Farmitalia Carlo Erba Curated by ChEMBL | Assay Description In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees centigrade | J Med Chem 37: 3588-604 (1994) BindingDB Entry DOI: 10.7270/Q2C24VFD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50002805 ((daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-e...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents | PubMed | n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Zeria Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description In vitro thromboxane A2 antagonistic activity on aggregation of rabbit platelets induced by U-46,619 (4 uM) | Bioorg Med Chem Lett 9: 401-6 (1999) BindingDB Entry DOI: 10.7270/Q2GB2363 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid TP receptor (Homo sapiens (Human)) | BDBM50002805 ((daltroban){4-[2-(4-Chloro-benzenesulfonylamino)-e...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia-Farmitalia Carlo Erba Curated by ChEMBL | Assay Description In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human platelets | J Med Chem 37: 3588-604 (1994) BindingDB Entry DOI: 10.7270/Q2C24VFD | |||||||||||
More data for this Ligand-Target Pair |