BDBM50003358 5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine::CHEMBL307645

SMILES: CN1CCC=C(C1)c1nsnc1Cl

InChI Key: InChIKey=GHSRKHUQMJRXQN-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50003358   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50003358 (5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...) Show SMILES CN1CCC=C(C1)c1nsnc1Cl |c:4| Show InChI InChI=1S/C8H10ClN3S/c1-12-4-2-3-6(5-12)7-8(9)11-13-10-7/h3H,2,4-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	375	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk CNS Division Curated by ChEMBL					Assay Description In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand				J Med Chem 35: 2274-83 (1992) BindingDB Entry DOI: 10.7270/Q22J69TH
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50003358 (5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...) Show SMILES CN1CCC=C(C1)c1nsnc1Cl |c:4| Show InChI InChI=1S/C8H10ClN3S/c1-12-4-2-3-6(5-12)7-8(9)11-13-10-7/h3H,2,4-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk CNS Division Curated by ChEMBL					Assay Description In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand				J Med Chem 35: 2274-83 (1992) BindingDB Entry DOI: 10.7270/Q22J69TH
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50003358 (5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...) Show SMILES CN1CCC=C(C1)c1nsnc1Cl |c:4| Show InChI InChI=1S/C8H10ClN3S/c1-12-4-2-3-6(5-12)7-8(9)11-13-10-7/h3H,2,4-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	375	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligand				J Med Chem 35: 4011-9 (1992) BindingDB Entry DOI: 10.7270/Q2KW5F1K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50003358 (5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...) Show SMILES CN1CCC=C(C1)c1nsnc1Cl |c:4| Show InChI InChI=1S/C8H10ClN3S/c1-12-4-2-3-6(5-12)7-8(9)11-13-10-7/h3H,2,4-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1				J Med Chem 35: 4011-9 (1992) BindingDB Entry DOI: 10.7270/Q2KW5F1K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50003358 (5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...) Show SMILES CN1CCC=C(C1)c1nsnc1Cl |c:4| Show InChI InChI=1S/C8H10ClN3S/c1-12-4-2-3-6(5-12)7-8(9)11-13-10-7/h3H,2,4-5H2,1H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	537	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferens				J Med Chem 35: 4011-9 (1992) BindingDB Entry DOI: 10.7270/Q2KW5F1K
					More data for this Ligand-Target Pair