BDBM50003470 5-Amino-2-{4-[(5-fluoro-2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanoic acid::CHEMBL339240

SMILES: Cc1nc2ccc(NCc3ccc(cc3)C(=O)NC(CCCN)C(O)=O)c(F)c2c(=O)[nH]1

InChI Key: InChIKey=BETGUEQQQUIULC-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Folylpoly-gamma-glutamate synthetase (Homo sapiens (Human))	BDBM50003470 (5-Amino-2-{4-[(5-fluoro-2-methyl-4-oxo-3,4-dihydro...) Show SMILES Cc1nc2ccc(NCc3ccc(cc3)C(=O)NC(CCCN)C(O)=O)c(F)c2c(=O)[nH]1 Show InChI InChI=1S/C22H24FN5O4/c1-12-26-15-8-9-16(19(23)18(15)21(30)27-12)25-11-13-4-6-14(7-5-13)20(29)28-17(22(31)32)3-2-10-24/h4-9,17,25H,2-3,10-11,24H2,1H3,(H,28,29)(H,31,32)(H,26,27,30)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)				J Med Chem 35: 4078-85 (1992) BindingDB Entry DOI: 10.7270/Q26M35S6
					More data for this Ligand-Target Pair