BDBM50004051 2-Amino-4-phosphono-butyric acid::2-Amino-4-phosphono-butyric acid (AP4)::4-Amino Phosphonobutyrate::CHEMBL285843::GlcN-6-P synthase inhibitor, 1 (racemic mixture)::L-AP4

SMILES: NC(CCP(O)(O)=O)C(O)=O

InChI Key: InChIKey=DDOQBQRIEWHWBT-UHFFFAOYSA-N

Data: 14 KI  2 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50004051   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 6 (mGlu6) (Rattus norvegicus (Rat))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	398	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 131-42 (2003) Article DOI: 10.1124/jpet.102.047092 BindingDB Entry DOI: 10.7270/Q2VT1QN7
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	398	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 131-42 (2003) Article DOI: 10.1124/jpet.102.047092 BindingDB Entry DOI: 10.7270/Q2VT1QN7
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP Ki Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
					More data for this Ligand-Target Pair
GRM8 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP Ki Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UPR Centre Curated by PDSP Ki Database									Mol Pharmacol 50: 923-30 (1996) BindingDB Entry DOI: 10.7270/Q2M61HS5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by PDSP Ki Database									J Neurochem 71: 2558-64 (1998) Article DOI: 10.1046/j.1471-4159.1998.71062558.x BindingDB Entry DOI: 10.7270/Q25D8QCZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP Ki Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8) (Rattus norvegicus (Rat))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Case Western Reserve University Curated by PDSP Ki Database									J Pharmacol Exp Ther 305: 131-42 (2003) Article DOI: 10.1124/jpet.102.047092 BindingDB Entry DOI: 10.7270/Q2VT1QN7
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by PDSP Ki Database									Mol Pharmacol 53: 228-33 (1998) BindingDB Entry DOI: 10.7270/Q2MP51T5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Curated by PDSP Ki Database									J Neurochem 75: 2590-601 (2000) Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ
					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by PDSP Ki Database									J Pharmacol Exp Ther 298: 453-60 (2001) Article DOI: 10.1016/j.bioorg.2016.02.004 BindingDB Entry DOI: 10.7270/Q2V986M2
					More data for this Ligand-Target Pair
GRM7 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP Ki Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Curated by PDSP Ki Database									J Neurochem 75: 2590-601 (2000) Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ
					More data for this Ligand-Target Pair
Glucosamine-6- Phosphate Synthase (Candida albicans)	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars		1.20E+7	n/a	2.60E+7	n/a	n/a	n/a	n/a	6.85	n/a
Technical University of Gdansk					Assay Description Two assays of GlcN-6-P synthase activity were used 1)determination of GlcN-6_P formation by the modified Elson-Morgan procedure and 2) continuous qua...				Bioorg Chem 25: 283-296 (1997) BindingDB Entry DOI: 10.7270/Q2RB7351
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Compound was tested for the inhibition of Metabotropic glutamate receptor 4				J Med Chem 41: 1641-50 (1998) Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Compound was tested for the inhibition of Metabotropic glutamate receptor 6				J Med Chem 41: 1641-50 (1998) Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6) (Rattus norvegicus (Rat))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 6				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
					More data for this Ligand-Target Pair
GRM8 (Homo sapiens (Human))	BDBM50004051 (2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...) Show SMILES NC(CCP(O)(O)=O)C(O)=O Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8				Bioorg Med Chem Lett 15: 349-51 (2004) Article DOI: 10.1016/j.bmcl.2004.10.093 BindingDB Entry DOI: 10.7270/Q2G161M2
					More data for this Ligand-Target Pair				3D Structure (crystal)