BDBM50004169 (2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo[3.2.1]octane::3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza-bicyclo[3.2.1]octane::CHEMBL281288
SMILES: CN1C2CCC1[C@@H](C=C)[C@H](C2)c1ccc(Cl)cc1
InChI Key: InChIKey=IABCSXAJRAMENM-PWUWZPNHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50004169 ((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research Curated by ChEMBL | Assay Description Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes. | J Med Chem 38: 3086-93 (1995) BindingDB Entry DOI: 10.7270/Q2KS6S69 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50004169 ((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporter | J Med Chem 38: 3086-93 (1995) BindingDB Entry DOI: 10.7270/Q2KS6S69 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50004169 ((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Ability to displace [3H]-Mazindol from dopamine receptor | Bioorg Med Chem Lett 3: 1327-1332 (1993) Article DOI: 10.1016/S0960-894X(00)80341-8 BindingDB Entry DOI: 10.7270/Q2RJ4JZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50004169 ((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory concentration against [3H]dopamine uptake | Bioorg Med Chem Lett 3: 1327-1332 (1993) Article DOI: 10.1016/S0960-894X(00)80341-8 BindingDB Entry DOI: 10.7270/Q2RJ4JZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50004169 ((2S,3S)-3-(4-Chloro-phenyl)-8-methyl-2-vinyl-8-aza...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Education and Research Curated by ChEMBL | Assay Description Compound was evaluated for its ability to displace [3H]mazindol binding from rat striatal membranes | J Med Chem 35: 4764-6 (1993) BindingDB Entry DOI: 10.7270/Q2QR4XQT | |||||||||||
More data for this Ligand-Target Pair |