BDBM50004734 CHEMBL310852::N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide::N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide (BM 5)::N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide (R)::N-Methyl-N-(1-methyl-4-pyrrolidin-1-yl-but-2-ynyl)-acetamide (S)
SMILES: CC(C#CCN1CCCC1)N(C)C(C)=O
InChI Key: InChIKey=VHYUYQHTMPWAPK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.860 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Company Curated by ChEMBL | Assay Description Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro) | J Med Chem 34: 2314-27 (1991) BindingDB Entry DOI: 10.7270/Q2057J5V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]CD as a radioligand. | J Med Chem 33: 3190-8 (1990) BindingDB Entry DOI: 10.7270/Q2M32Z0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company Curated by ChEMBL | Assay Description Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex. | J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Company Curated by ChEMBL | Assay Description Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro) | J Med Chem 34: 2314-27 (1991) BindingDB Entry DOI: 10.7270/Q2057J5V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]PZ as a radioligand. | J Med Chem 33: 3190-8 (1990) BindingDB Entry DOI: 10.7270/Q2M32Z0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company Curated by ChEMBL | Assay Description Binding affinity at [3H]PZ radiolabeled muscarinic M1 receptor in rat cortex. | J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Uppsala Curated by ChEMBL | Assay Description Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum | J Med Chem 35: 3270-9 (1992) BindingDB Entry DOI: 10.7270/Q2KP813K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Uppsala Curated by ChEMBL | Assay Description Compound was tested for the concentration that inhibited the specific binding of (-)-[3H]-NMS to muscarinic receptor in the rat cerebral cortex. | J Med Chem 32: 863-9 (1989) BindingDB Entry DOI: 10.7270/Q2TQ63RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Uppsala Curated by ChEMBL | Assay Description Inhibition of [3H]N-methylscopolamine binding to muscarinic acetylcholine receptor of rat cerebral cortex. | J Med Chem 35: 285-94 (1992) BindingDB Entry DOI: 10.7270/Q28G8NXX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]-QNB as a radioligand. | J Med Chem 33: 3190-8 (1990) BindingDB Entry DOI: 10.7270/Q2M32Z0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company Curated by ChEMBL | Assay Description Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex. | J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company Curated by ChEMBL | Assay Description Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex. | J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Binding activity against Muscarinic acetylcholine receptor in rat cortex, using [3H]QNB as a radioligand. | J Med Chem 33: 3190-8 (1990) BindingDB Entry DOI: 10.7270/Q2M32Z0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company Curated by ChEMBL | Assay Description Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assay | J Med Chem 33: 3190-8 (1990) BindingDB Entry DOI: 10.7270/Q2M32Z0K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company Curated by ChEMBL | Assay Description Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart. | J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (Homo sapiens (Human)) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK Curated by ChEMBL | Assay Description Binding affinity was determined using [3H]-NMS for Muscarinic acetylcholine receptor in SK-N-SH neuroblastoma cells | J Med Chem 33: 741-8 (1990) BindingDB Entry DOI: 10.7270/Q2NV9JTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (RAT) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK Curated by ChEMBL | Assay Description Muscarinic acetylcholine receptor binding affinity was determined using [3H]NMS for NG108-15 neuroblastoma cells | J Med Chem 33: 741-8 (1990) BindingDB Entry DOI: 10.7270/Q2NV9JTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (Homo sapiens (Human)) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a |
University of Uppsala Curated by ChEMBL | Assay Description Equilibrium dissociation constant muscarinic receptor complex, measured in guinea pig ileum | J Med Chem 31: 577-82 (1988) BindingDB Entry DOI: 10.7270/Q2TX3HMS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Cavia porcellus) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 190 | n/a | n/a | n/a | n/a |
University of Uppsala Curated by ChEMBL | Assay Description Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assay | J Med Chem 35: 3270-9 (1992) BindingDB Entry DOI: 10.7270/Q2KP813K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Cavia porcellus) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a |
University of Uppsala Curated by ChEMBL | Assay Description Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum | J Med Chem 35: 3270-9 (1992) BindingDB Entry DOI: 10.7270/Q2KP813K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor (Homo sapiens (Human)) | BDBM50004734 (CHEMBL310852 | N-Methyl-N-(1-methyl-4-pyrrolidin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a |
University of Uppsala Curated by ChEMBL | Assay Description Determination of dissociation constant from antimuscarinic activity on isolated guinea pig ileum. | J Med Chem 35: 285-94 (1992) BindingDB Entry DOI: 10.7270/Q28G8NXX | |||||||||||
More data for this Ligand-Target Pair |