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Enter Data

BDBM50004735 1-(4-Pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-one::CHEMBL76385

SMILES: O=C1NCCN1CC#CCN1CCCC1

InChI Key: InChIKey=NNQOKFWDPAVGRK-UHFFFAOYSA-N

Data: 3 KI 1 Kd 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50004735
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor (RAT)	BDBM50004735 (1-(4-Pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-on...) Show SMILES O=C1NCCN1CC#CCN1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro)				J Med Chem 34: 2314-27 (1991) BindingDB Entry DOI: 10.7270/Q2057J5V
Upjohn Company Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor (RAT)	BDBM50004735 (1-(4-Pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-on...) Show SMILES O=C1NCCN1CC#CCN1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro)				J Med Chem 34: 2314-27 (1991) BindingDB Entry DOI: 10.7270/Q2057J5V
Upjohn Company Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor (RAT)	BDBM50004735 (1-(4-Pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-on...) Show SMILES O=C1NCCN1CC#CCN1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Uppsala Curated by ChEMBL					Assay Description Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum				J Med Chem 35: 3270-9 (1992) BindingDB Entry DOI: 10.7270/Q2KP813K
University of Uppsala Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM50004735 (1-(4-Pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-on...) Show SMILES O=C1NCCN1CC#CCN1CCCC1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.67E+3	n/a	n/a	n/a	n/a
University of Uppsala Curated by ChEMBL					Assay Description Inhibition of Shh signaling in mouse Shh-light2 cells by Gli-dependent firefly luciferase reporter gene assay				J Med Chem 35: 3270-9 (1992) BindingDB Entry DOI: 10.7270/Q2KP813K
University of Uppsala Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Cavia porcellus)	BDBM50004735 (1-(4-Pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-on...) Show SMILES O=C1NCCN1CC#CCN1CCCC1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	3.03E+4	n/a	n/a	n/a	n/a	n/a
University of Uppsala Curated by ChEMBL					Assay Description Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum				J Med Chem 35: 3270-9 (1992) BindingDB Entry DOI: 10.7270/Q2KP813K
University of Uppsala Curated by ChEMBL					More data for this Ligand-Target Pair