Found 10 hits for monomerid = 50004955 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Steroid 5-alpha-reductase
(Homo sapiens (Human)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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Similars
| PubMed
| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition constant against recombinant human Steroid 5-alpha-reductase type 2 expressed in CHO cells |
J Med Chem 38: 13-5 (1995)
BindingDB Entry DOI: 10.7270/Q2D50P5K |
More data for this Ligand-Target Pair | |
D-Amino Acid Oxidase (DAAO)
(Sus scrofa (pig)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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| Article PubMed
| 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Competitive inhibition of pig kidney DAAO in presence of D-alanine |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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| Article PubMed
| >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description Displacement of FITC-Bak-BH3 peptide from Mcl-1 (unknown origin) incubated for 1.5 hrs by FPA competition assay |
J Med Chem 58: 3794-805 (2015)
Article DOI: 10.1021/jm501984f BindingDB Entry DOI: 10.7270/Q24X59HH |
More data for this Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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| Article PubMed
| >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description Displacement of FITC-AHx-KALETLRRVGDGVQRNHETAF-NH2 from human MCl1 (172 to 327) expressed in Escherichia coli BL21 (DE3) after 1 hr by fluorescence p... |
J Med Chem 56: 15-30 (2013)
Article DOI: 10.1021/jm301448p BindingDB Entry DOI: 10.7270/Q29G5P46 |
More data for this Ligand-Target Pair | |
Alpha-chymotrypsin
(Bos taurus (bovine)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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| 4.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
California Institute of Technology
| Assay Description Kinetic assay using chymotrypsin. |
Biochemistry 4: 99-104 (1965)
Article DOI: 10.1021/bi00877a017 BindingDB Entry DOI: 10.7270/Q23N2214 |
More data for this Ligand-Target Pair | |
Alpha-chymotrypsin
(Bos taurus (bovine)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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| 4.40E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
California Institute of Technology
| Assay Description Kinetic assay using chymotrypsin. |
Biochemistry 4: 99-104 (1965)
Article DOI: 10.1021/bi00877a017 BindingDB Entry DOI: 10.7270/Q23N2214 |
More data for this Ligand-Target Pair | |
Alpha-chymotrypsin
(Bos taurus (bovine)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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| 4.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
California Institute of Technology
| Assay Description Kinetic assay using chymotrypsin. |
Biochemistry 4: 99-104 (1965)
Article DOI: 10.1021/bi00877a017 BindingDB Entry DOI: 10.7270/Q23N2214 |
More data for this Ligand-Target Pair | |
Alpha-chymotrypsin
(Bos taurus (bovine)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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| 5.70E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
California Institute of Technology
| Assay Description Kinetic assay using chymotrypsin. |
Biochemistry 4: 99-104 (1965)
Article DOI: 10.1021/bi00877a017 BindingDB Entry DOI: 10.7270/Q23N2214 |
More data for this Ligand-Target Pair | |
D-Aspartate Oxidase (DDO)
(Homo sapiens (Human)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Inhibition of human DDO |
Bioorg Med Chem Lett 18: 3386-91 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.020 BindingDB Entry DOI: 10.7270/Q2WQ03KS |
More data for this Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50004955
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 745 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Inhibition of human DAO |
Bioorg Med Chem Lett 18: 3386-91 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.020 BindingDB Entry DOI: 10.7270/Q2WQ03KS |
More data for this Ligand-Target Pair | |