BDBM50005212 CHEMBL3109275

SMILES: CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc(cc(c2)-c2ccccn2)-c2cccnc2)c1

InChI Key: InChIKey=SELRMMCYEMBVON-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50005212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50005212 (CHEMBL3109275) Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc(cc(c2)-c2ccccn2)-c2cccnc2)c1 Show InChI InChI=1S/C28H24N4O4S/c1-3-37(33,34)23-9-10-26(35-2)25(16-23)32-28-31-18-27(36-28)22-14-20(19-7-6-11-29-17-19)13-21(15-22)24-8-4-5-12-30-24/h4-18H,3H2,1-2H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Comenius University Curated by ChEMBL					Assay Description Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay				Eur J Med Chem 72: 146-59 (2014) Article DOI: 10.1016/j.ejmech.2013.11.023 BindingDB Entry DOI: 10.7270/Q2K93919
					More data for this Ligand-Target Pair