BindingDB PrimarySearch

BDBM50005232 (R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-propoxycarbonyl)-amino]-methyl}-1-ethyl-pyridinium; chloride::(S)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-propoxycarbonyl)-amino]-methyl}-1-ethyl-pyridinium; chloride::2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-propoxycarbonyl)-amino]-methyl}-1-ethyl-pyridinium; chloride::2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-propoxycarbonyl)-amino]-methyl}-1-ethyl-pyridinium; iodide::CHEMBL274420::CV-6209

SMILES: CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC

InChI Key: InChIKey=LSUANMYXNFBGDT-UHFFFAOYSA-O

Data: 4 KI 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50005232
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Platelet activating factor receptor (Homo sapiens (Human))	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhone-Poulenc Sante Curated by PDSP K_i Database									J Pharmacol Exp Ther 252: 1221-7 (1990) BindingDB Entry DOI: 10.7270/Q2JW8CC2
Rhone-Poulenc Sante Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Platelet activating factor receptor (Homo sapiens (Human))	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhone-Poulenc Sante Curated by PDSP K_i Database									J Pharmacol Exp Ther 252: 1221-7 (1990) BindingDB Entry DOI: 10.7270/Q2JW8CC2
Rhone-Poulenc Sante Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro ability to displace [3H]-PAF from PAF receptor in rabbit platelet membranes				Bioorg Med Chem Lett 5: 1097-1102 (1995) Article DOI: 10.1016/0960-894X(95)00174-R BindingDB Entry DOI: 10.7270/Q2NZ87KQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Ability to displace [3H]-PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.				Bioorg Med Chem Lett 5: 1091-1096 (1995) Article DOI: 10.1016/0960-894X(95)00173-Q BindingDB Entry DOI: 10.7270/Q2SQ90BW
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.				Bioorg Med Chem Lett 5: 1091-1096 (1995) Article DOI: 10.1016/0960-894X(95)00173-Q BindingDB Entry DOI: 10.7270/Q2SQ90BW
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
J. Uriach & Cía.S.A. Curated by ChEMBL					Assay Description Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%				J Med Chem 34: 373-86 (1991) BindingDB Entry DOI: 10.7270/Q2DF6Q51
J. Uriach & Cía.S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets				Bioorg Med Chem Lett 5: 1097-1102 (1995) Article DOI: 10.1016/0960-894X(95)00174-R BindingDB Entry DOI: 10.7270/Q2NZ87KQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
J. Uriach & Cía.S.A. Curated by ChEMBL					Assay Description Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%				J Med Chem 34: 373-86 (1991) BindingDB Entry DOI: 10.7270/Q2DF6Q51
J. Uriach & Cía.S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries Ltd. Curated by ChEMBL					Assay Description Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)				J Med Chem 32: 56-64 (1989) BindingDB Entry DOI: 10.7270/Q2ZP46QM
Takeda Chemical Industries Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
American Cyanamid Company Curated by ChEMBL					Assay Description Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma				J Med Chem 36: 580-90 (1993) BindingDB Entry DOI: 10.7270/Q2SX6C9X
American Cyanamid Company Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet activating factor receptor (Cavia porcellus)	BDBM50005232 ((R)-2-{[Acetyl-(2-methoxy-3-octadecylcarbamoyloxy-...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
J. Uriach & Cía.S.A. Curated by ChEMBL					Assay Description In vitro inhibition of PAF induced aggregation of rabbit platelets.				J Med Chem 35: 676-83 (1992) BindingDB Entry DOI: 10.7270/Q298860P
J. Uriach & Cía.S.A. Curated by ChEMBL					More data for this Ligand-Target Pair