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BDBM50005265 (+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine::(-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine::(Rec)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine; compound with 2-(2,5-dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine::2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine::2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine((R)-(-)-DOM)::2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine(DOM)::CHEMBL8600::DOM::DOM,R(-)::Racemic DOM
SMILES: COc1cc(CC(C)N)c(OC)cc1C
InChI Key: InChIKey=NTJQREUGJKIARY-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Curated by PDSP Ki Database | J Neurosci 9: 3482-90 (1989) BindingDB Entry DOI: 10.7270/Q2FX77Z2 | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Effect on plasma amine oxidase (0.1 uM) after 15 min of incubation at pH 7.2 | J Med Chem 31: 867-70 (1988) BindingDB Entry DOI: 10.7270/Q2QN65SB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 2 receptor from rat frontal cortex using [125]-(R)-DOI as radioligand | J Med Chem 38: 3593-601 (1995) Article DOI: 10.1021/jm00018a019 BindingDB Entry DOI: 10.7270/Q2PC3535 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Compound was evaluated for its ability to displace [125I]-(R)-DOI from 5-hydroxytryptamine 2A receptor in cloned rat prefrontal cortex homogenate | Bioorg Med Chem Lett 12: 1997-9 (2002) BindingDB Entry DOI: 10.7270/Q2BR8RH5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Compound was evaluated for its ability to displace 0.25 nM [125I](R)-DOI from binding sites in rat frontal cortex. | J Med Chem 34: 276-81 (1991) BindingDB Entry DOI: 10.7270/Q2SN0C6J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Albany Medical College Curated by PDSP Ki Database | Synapse 35: 144-50 (2000) Article DOI: 10.1002/(SICI)1098-2396(200002)35:2<144::AID-SYN7>3.0.CO;2-K BindingDB Entry DOI: 10.7270/Q2ST7NDX | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 41.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by PDSP Ki Database | Neuropharmacology 33: 275-317 (1994) Article DOI: 10.1016/0028-3908(94)90059-0 BindingDB Entry DOI: 10.7270/Q2M043X2 | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 2 receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]ketanserin as... | J Med Chem 35: 734-40 (1992) BindingDB Entry DOI: 10.7270/Q29K4BV4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 2 receptor of rat frontal cortex using [3H]ketanserin radioligand | J Med Chem 33: 1032-6 (1990) BindingDB Entry DOI: 10.7270/Q2319Z37 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligand | J Med Chem 30: 1-12 (1987) BindingDB Entry DOI: 10.7270/Q29K4BS7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopy | Bioorg Med Chem 16: 4661-9 (2008) Article DOI: 10.1016/j.bmc.2008.02.033 BindingDB Entry DOI: 10.7270/Q25D8RNZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Effect on plasma amine oxidase (0.1 uM) after 30 min of incubation at pH 7.2 | J Med Chem 31: 867-70 (1988) BindingDB Entry DOI: 10.7270/Q2QN65SB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 193 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]mesulergine ... | J Med Chem 35: 734-40 (1992) BindingDB Entry DOI: 10.7270/Q29K4BV4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 306 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Albany Medical College Curated by PDSP Ki Database | Synapse 35: 144-50 (2000) Article DOI: 10.1002/(SICI)1098-2396(200002)35:2<144::AID-SYN7>3.0.CO;2-K BindingDB Entry DOI: 10.7270/Q2ST7NDX | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 372 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta Curated by PDSP Ki Database | Neuropharmacology 33: 275-317 (1994) Article DOI: 10.1016/0028-3908(94)90059-0 BindingDB Entry DOI: 10.7270/Q2M043X2 | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| HTR2B (BOVINE) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | Reactome pathway UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Curated by PDSP Ki Database | J Neurosci 9: 3482-90 (1989) BindingDB Entry DOI: 10.7270/Q2FX77Z2 | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 1B/1D receptor (Rattus norvegicus (Rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 2.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity against 5-HT1B serotonin receptor in rat striatum | J Med Chem 31: 867-70 (1988) BindingDB Entry DOI: 10.7270/Q2QN65SB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin 1 (5-HT1) receptor (RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 2.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand. | J Med Chem 30: 1-12 (1987) BindingDB Entry DOI: 10.7270/Q29K4BS7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | 5.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampal tissue | J Med Chem 31: 867-70 (1988) BindingDB Entry DOI: 10.7270/Q2QN65SB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 7.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation Curated by PDSP Ki Database | Biochem Pharmacol 45: 375-83 (1993) Article DOI: 10.1016/0006-2952(93)90073-6 BindingDB Entry DOI: 10.7270/Q2BZ64JG | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Monoamine oxidase (Rattus norvegicus (rat)) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Chile Curated by ChEMBL | Assay Description Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspension | J Med Chem 48: 2407-19 (2005) Article DOI: 10.1021/jm0493109 BindingDB Entry DOI: 10.7270/Q27080XX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serotonin receptor 2a and 2b (5HT2A and 5HT2B) (RAT) | BDBM50005265 ((+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-et...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | 75.9 | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus | J Med Chem 24: 1414-21 (1982) BindingDB Entry DOI: 10.7270/Q2SX6FD3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
