BindingDB PrimarySearch_ki

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Enter Data

BDBM50005322 CHEMBL353813::[6-(2-Amino-1,6,7,8-tetrahydro-imidazo[4,5-g]quinolin-5-ylmethyl)-naphthalen-2-yl]-methanol

SMILES: Nc1nc2cc3CCCN(Cc4ccc5cc(CO)ccc5c4)c3cc2[nH]1

InChI Key: InChIKey=SLCHNYIKJBZPFO-UHFFFAOYSA-N

Data: 2 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50005322
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thymidylate synthase (Homo sapiens (Human))	BDBM50005322 (CHEMBL353813 \| [6-(2-Amino-1,6,7,8-tetrahydro-imid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human Thymidylate synthase (TS)				J Med Chem 35: 847-58 (1992) BindingDB Entry DOI: 10.7270/Q2X0660R
Agouron Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Escherichia coli)	BDBM50005322 (CHEMBL353813 \| [6-(2-Amino-1,6,7,8-tetrahydro-imid...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Agouron Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Escherichia coli Thymidylate synthase (TS)				J Med Chem 35: 847-58 (1992) BindingDB Entry DOI: 10.7270/Q2X0660R
Agouron Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair