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BDBM50005480 (-)-combretastatin::(Z)-3'-hydroxy-3,4,4',5-tetramethoxystilbene::(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::(combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::(combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-methoxy-5-(3,4,5-trimethoxystyryl)phenol::2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol::5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol::CHEMBL67::Combrestatin A-4::Combrestatin A4::Combretastastin A-4::Combretastatin::Combretastatin-A4::Combretastin A-4::Z-Combretastatin A-4::combretastatin A-4, (CSA4)::combretastin A4
SMILES: COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
InChI Key: InChIKey=HVXBOLULGPECHP-WAYWQWQTSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet  | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Minia University Curated by ChEMBL | Assay Description Inhibition of [3H] colchicine binding to bovine brain tubulin incubated for 30 mins by scintillation proximity assay | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111697 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding constant at colchicine site of bovine brain tubulin | Bioorg Med Chem Lett 12: 465-9 (2002) BindingDB Entry DOI: 10.7270/Q2PC32W7 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Tubulin (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia | Assay Description Tubulin polymerization was followed turbidimetrically at 350nm in Beckman model DU-7400 and DU-7500 spectrophotometers equipped with electric tempera... | Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia | Assay Description IC50 values for inhibition of cell growth using MCF-7 cell line were obtained by measuring the amount of total cell protein with the sulforhodamine B... | Chem Biol 12: 1007-14 (2005) Article DOI: 10.1016/j.chembiol.2005.06.016 BindingDB Entry DOI: 10.7270/Q2DN43HC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization | J Med Chem 37: 1126-35 (1994) BindingDB Entry DOI: 10.7270/Q2ZC81XN | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill 27599 Curated by ChEMBL | Assay Description Inhibition of bovine tubulin polymerization | J Med Chem 40: 2266-75 (1997) Article DOI: 10.1021/jm960858s BindingDB Entry DOI: 10.7270/Q26M35ZF | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Padova Curated by ChEMBL | Assay Description Inhibition of EGFR (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysi... | J Med Chem 57: 4598-605 (2014) Article DOI: 10.1021/jm500034j BindingDB Entry DOI: 10.7270/Q2KH0PW0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Padova Curated by ChEMBL | Assay Description Inhibition of FGFR1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analys... | J Med Chem 57: 4598-605 (2014) Article DOI: 10.1021/jm500034j BindingDB Entry DOI: 10.7270/Q2KH0PW0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Padova Curated by ChEMBL | Assay Description Inhibition of Abl1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysi... | J Med Chem 57: 4598-605 (2014) Article DOI: 10.1021/jm500034j BindingDB Entry DOI: 10.7270/Q2KH0PW0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Padova Curated by ChEMBL | Assay Description Inhibition of Src (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysis | J Med Chem 57: 4598-605 (2014) Article DOI: 10.1021/jm500034j BindingDB Entry DOI: 10.7270/Q2KH0PW0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin (Sus scrofa (Pig)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Antitubulin activity activity of the compound against tubulin polymerization | J Med Chem 42: 5475-81 (2000) BindingDB Entry DOI: 10.7270/Q29S1Q7J | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin (Sus scrofa (Pig)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Arizona State University Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization | J Med Chem 43: 2731-7 (2000) BindingDB Entry DOI: 10.7270/Q2SX6CFQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin (Sus scrofa (Pig)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Concentration required to inhibit polymerization of tubulin | Bioorg Med Chem Lett 11: 871-4 (2001) BindingDB Entry DOI: 10.7270/Q25X2867 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin (Sus scrofa (Pig)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Australian National University Curated by ChEMBL | Assay Description Compound was evaluated for inhibition of tubulin polymerization | Bioorg Med Chem Lett 11: 2341-3 (2001) BindingDB Entry DOI: 10.7270/Q2WH2P8G | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin (Sus scrofa (Pig)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization(ITP) | J Med Chem 44: 3932-6 (2001) BindingDB Entry DOI: 10.7270/Q2PK0FFW | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Concentration needed to inhibit tubulin polymerization by 50% | J Med Chem 45: 1697-711 (2002) BindingDB Entry DOI: 10.7270/Q2QJ7GKQ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin alpha chain /beta chain (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentration | J Med Chem 46: 1670-82 (2003) Article DOI: 10.1021/jm020292+ BindingDB Entry DOI: 10.7270/Q2HD7V1V | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization | Bioorg Med Chem Lett 25: 631-4 (2015) Article DOI: 10.1016/j.bmcl.2014.12.004 BindingDB Entry DOI: 10.7270/Q2DN46PV | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method | Bioorg Med Chem 22: 4285-92 (2014) Article DOI: 10.1016/j.bmc.2014.05.029 BindingDB Entry DOI: 10.7270/Q21Z462G | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method | Bioorg Med Chem 22: 4312-22 (2014) Article DOI: 10.1016/j.bmc.2014.05.017 BindingDB Entry DOI: 10.7270/Q2TF000J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Padova Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetry | Eur J Med Chem 84: 476-90 (2014) Article DOI: 10.1016/j.ejmech.2014.07.050 BindingDB Entry DOI: 10.7270/Q2VH5QGD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Padova Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetry | Eur J Med Chem 84: 476-90 (2014) Article DOI: 10.1016/j.ejmech.2014.07.050 BindingDB Entry DOI: 10.7270/Q2VH5QGD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Ferrara Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization by turbidimetry | J Med Chem 57: 6795-808 (2014) Article DOI: 10.1021/jm5008193 BindingDB Entry DOI: 10.7270/Q26111Z5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin beta-1 chain (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization | J Med Chem 47: 4247-57 (2004) Article DOI: 10.1021/jm049802l BindingDB Entry DOI: 10.7270/Q2N87987 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta tubulin (Leishmania donovani) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization interacting at the colchicine binding site. | Bioorg Med Chem Lett 15: 1051-4 (2005) Article DOI: 10.1016/j.bmcl.2004.12.026 BindingDB Entry DOI: 10.7270/Q22Z151S | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin beta-1 chain (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salford Curated by ChEMBL | Assay Description Concentration required for 50% inhibition of tubulin polymerization | J Med Chem 48: 457-65 (2005) Article DOI: 10.1021/jm049444m BindingDB Entry DOI: 10.7270/Q2416WKV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin preincubated for 20 mins by turbidimetry | Eur J Med Chem 85: 341-51 (2014) Article DOI: 10.1016/j.ejmech.2014.07.082 BindingDB Entry DOI: 10.7270/Q29C7036 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta tubulin (Leishmania donovani) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitá di Ferrara Curated by ChEMBL | Assay Description Concentration required to inhibit tubulin polymerization at 10 uM | Bioorg Med Chem Lett 15: 4048-52 (2005) Article DOI: 10.1016/j.bmcl.2005.06.022 BindingDB Entry DOI: 10.7270/Q2XP74GG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin assembly | Bioorg Med Chem 23: 2408-23 (2015) Article DOI: 10.1016/j.bmc.2015.03.061 BindingDB Entry DOI: 10.7270/Q2765H1D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Second Military Medical University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization incubated for 60 mins by microplate reader based turbidimetry | J Med Chem 58: 2538-46 (2015) Article DOI: 10.1021/acs.jmedchem.5b00118 BindingDB Entry DOI: 10.7270/Q24M966N | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Ferrara Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysis | J Med Chem 58: 3209-22 (2015) Article DOI: 10.1021/acs.jmedchem.5b00155 BindingDB Entry DOI: 10.7270/Q2QV3P6V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric analysis | Eur J Med Chem 94: 447-57 (2015) Article DOI: 10.1016/j.ejmech.2015.02.058 BindingDB Entry DOI: 10.7270/Q2SN0BQV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin alpha chain /beta chain (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization extent after 20 mins by turbidimetrically | Eur J Med Chem 99: 125-37 (2015) Article DOI: 10.1016/j.ejmech.2015.05.021 BindingDB Entry DOI: 10.7270/Q2D50PP9 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin alpha chain /beta chain (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Taipei Medical University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization after 30 mins | Bioorg Med Chem 23: 4230-6 (2015) Article DOI: 10.1016/j.bmc.2015.06.043 BindingDB Entry DOI: 10.7270/Q2571DS7 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin alpha chain /beta chain (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Padova Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysis | J Med Chem 58: 7991-8010 (2015) BindingDB Entry DOI: 10.7270/Q29G5PMG | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Texas State University Curated by ChEMBL | Assay Description Inhibition of bovine tubulin assembly after 15 mins by turbidimetric analysis | J Med Chem 59: 480-5 (2016) BindingDB Entry DOI: 10.7270/Q2PV6N7Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Baylor University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysis | Bioorg Med Chem 24: 938-56 (2016) BindingDB Entry DOI: 10.7270/Q24Q7WVQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin (Sus scrofa (Pig)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Evaluated for the inhibitory concentration against porcine brain tubulin polymerization | Bioorg Med Chem Lett 4: 699-704 (1994) Article DOI: 10.1016/S0960-894X(01)80183-9 BindingDB Entry DOI: 10.7270/Q2P55NGK | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin beta chain (Sus scrofa) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assay | Bioorg Med Chem 24: 1729-40 (2016) BindingDB Entry DOI: 10.7270/Q22809G0 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Guru Nanak Dev University Curated by ChEMBL | Assay Description Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric meth... | Eur J Med Chem 116: 102-115 (2016) BindingDB Entry DOI: 10.7270/Q29S1SWW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tub... | Bioorg Med Chem Lett 3: 565-570 (1993) Article DOI: 10.1016/S0960-894X(01)81230-0 BindingDB Entry DOI: 10.7270/Q2F76D1R | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tubulin beta-1 chain (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Arizona State University Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization upon incubation for 20 min at 30 degree C | J Med Chem 48: 4087-99 (2005) Article DOI: 10.1021/jm0205797 BindingDB Entry DOI: 10.7270/Q23B60XC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| P-glycoprotein 1 (Homo sapiens (Human)) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assay | Bioorg Med Chem 21: 891-902 (2013) Article DOI: 10.1016/j.bmc.2012.12.010 BindingDB Entry DOI: 10.7270/Q2XP7692 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute Curated by ChEMBL | Assay Description Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2) | J Med Chem 35: 1058-67 (1992) BindingDB Entry DOI: 10.7270/Q2KS6TSB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute Curated by ChEMBL | Assay Description Concentration required to inhibit the extent of glutamate-dependent tubulin polymerization by 50% at 37 degrees C(1.0 mM MgCl2) | J Med Chem 35: 1058-67 (1992) BindingDB Entry DOI: 10.7270/Q2KS6TSB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Ability to inhibit Tubulin polymerization in Bovine brain | J Med Chem 34: 2579-88 (1991) BindingDB Entry DOI: 10.7270/Q2KW5J8Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tubulin beta chain (Sus scrofa) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo Curated by ChEMBL | Assay Description In vitro tubulin polymerization-inhibitory activity. | Bioorg Med Chem Lett 8: 1997-2000 (1998) BindingDB Entry DOI: 10.7270/Q2VH5R10 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization with preincubation for 15 minutes at 37 degree Centigrade prior to addition of the GTP required for polymerizati... | J Med Chem 36: 544-51 (1993) Article DOI: 10.1021/jm00057a004 BindingDB Entry DOI: 10.7270/Q2B56NGV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Evaluated for the inhibition of tubulin polymerization without pre-incubation | J Med Chem 36: 544-51 (1993) Article DOI: 10.1021/jm00057a004 BindingDB Entry DOI: 10.7270/Q2B56NGV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM50005480 ((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Inhibition of tubulin polymerization | J Med Chem 40: 3049-56 (1997) Article DOI: 10.1021/jm970146h BindingDB Entry DOI: 10.7270/Q2TQ648T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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