Found 15 hits for monomerid = 50006222 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Adenosylhomocysteinase
(Mus musculus) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Florida
Curated by ChEMBL
| Assay Description Binding affinity of the compound was tested against L929 cells AdoHcy hydrolase activity |
J Med Chem 37: 551-4 (1994)
BindingDB Entry DOI: 10.7270/Q2DJ5DQ4 |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Time course of inactivation of bovine liver S-adenosyl-homocysteine hydrolase |
J Med Chem 31: 500-3 (1988)
BindingDB Entry DOI: 10.7270/Q28P61Q3 |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against bovine liver S-adenosyl-L-homocysteine hydrolase (AdoHcy) rate of inactivation by NpcA |
J Med Chem 35: 1782-91 (1992)
BindingDB Entry DOI: 10.7270/Q23J3BW0 |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibition against bovine-liver S-Adenosyl-homocysteine (AdoHcy) hydrolase |
J Med Chem 31: 1729-38 (1988)
BindingDB Entry DOI: 10.7270/Q2HM5920 |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Rattus norvegicus) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company
Curated by ChEMBL
| Assay Description Reversible inhibition of rat liver S- adenosyl-L-homocysteine hydrolase using SAH as substrate by spectrophotometric method |
J Med Chem 63: 6315-6386 (2020)
|
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested for inhibitory concentration against S-adenosyl-homocysteine hydrolase |
Bioorg Med Chem Lett 3: 663-666 (1993)
Article DOI: 10.1016/S0960-894X(01)81249-X BindingDB Entry DOI: 10.7270/Q2X92BS9 |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Mus musculus) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Evaluated for the 50% inhibition of S-Adenosyl-homocysteine (AdoHcy) hydrolase L929 lysate from murine L-929 cells |
J Med Chem 31: 1729-38 (1988)
BindingDB Entry DOI: 10.7270/Q2HM5920 |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyo Jozo Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibitory effect against S-adenosyl-L-homocysteine hydrolase of rabbit erythrocyte. |
J Med Chem 35: 324-31 (1992)
BindingDB Entry DOI: 10.7270/Q2RX9B1R |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 15.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by ChEMBL
| Assay Description Inhibitory activity against S-adenosyl-L-homocysteine hydrolase from rabbit erythrocytes |
J Med Chem 39: 2392-9 (1996)
Article DOI: 10.1021/jm950853f BindingDB Entry DOI: 10.7270/Q2GM8B1S |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston College
Curated by ChEMBL
| Assay Description Inhibition of S-adenosyl-L-homocysteine hydrolase |
Bioorg Med Chem 17: 6707-14 (2009)
Article DOI: 10.1016/j.bmc.2009.07.061 BindingDB Entry DOI: 10.7270/Q2JD4X0D |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human placental AdoHcy hydrolase expressed in Escherichia coli BL21 using AdoHcy as substrate preincubated for 10 mins foll... |
J Med Chem 58: 5108-20 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00553 BindingDB Entry DOI: 10.7270/Q2T155DR |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against recombinant S-adenosyl-L-homocysteine hydrolase obtained from human placenta |
Bioorg Med Chem Lett 14: 2091-3 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.039 BindingDB Entry DOI: 10.7270/Q2DR2TXQ |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysis |
Bioorg Med Chem Lett 24: 2737-40 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.034 BindingDB Entry DOI: 10.7270/Q2VM4DTT |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 mins |
Bioorg Med Chem Lett 24: 2737-40 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.034 BindingDB Entry DOI: 10.7270/Q2VM4DTT |
More data for this Ligand-Target Pair | |
Adenosylhomocysteinase
(Homo sapiens (Human)) | BDBM50006222
((1S,2R,5R)-5-(6-Amino-purin-9-yl)-3-hydroxymethyl-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C=C(CO)[C@@H](O)[C@H]1O |r,t:13| Show InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University
Curated by ChEMBL
| Assay Description Inhibition of human placental AdoHcy hydrolase expressed in Escherichia coli JM109 |
J Med Chem 54: 930-8 (2011)
Article DOI: 10.1021/jm1010836 BindingDB Entry DOI: 10.7270/Q2D50N8H |
More data for this Ligand-Target Pair | |