BDBM50007086 CHEMBL3237558

SMILES: N[C@H]1CCCC[C@H]1Nc1cc(Nc2cccc(n2)C2CC2)c(nn1)C(N)=O

InChI Key: InChIKey=GEMHYLOIOLQZNH-GXTWGEPZSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50007086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50007086 (CHEMBL3237558) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc(Nc2cccc(n2)C2CC2)c(nn1)C(N)=O |r| Show InChI InChI=1S/C19H25N7O/c20-12-4-1-2-5-14(12)23-17-10-15(18(19(21)27)26-25-17)24-16-7-3-6-13(22-16)11-8-9-11/h3,6-7,10-12,14H,1-2,4-5,8-9,20H2,(H2,21,27)(H2,22,23,24,25)/t12-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50007086 (CHEMBL3237558) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc(Nc2cccc(n2)C2CC2)c(nn1)C(N)=O |r| Show InChI InChI=1S/C19H25N7O/c20-12-4-1-2-5-14(12)23-17-10-15(18(19(21)27)26-25-17)24-16-7-3-6-13(22-16)11-8-9-11/h3,6-7,10-12,14H,1-2,4-5,8-9,20H2,(H2,21,27)(H2,22,23,24,25)/t12-,14+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHO cells by patch clamp method				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50007086 (CHEMBL3237558) Show SMILES N[C@H]1CCCC[C@H]1Nc1cc(Nc2cccc(n2)C2CC2)c(nn1)C(N)=O |r| Show InChI InChI=1S/C19H25N7O/c20-12-4-1-2-5-14(12)23-17-10-15(18(19(21)27)26-25-17)24-16-7-3-6-13(22-16)11-8-9-11/h3,6-7,10-12,14H,1-2,4-5,8-9,20H2,(H2,21,27)(H2,22,23,24,25)/t12-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Inhibition of SYK in human whole blood assessed as anti-human IgM-induced CD69 protein expression preincubated for 30 mins followed by anti-human IgM...				J Med Chem 57: 2683-91 (2014) Article DOI: 10.1021/jm401982j BindingDB Entry DOI: 10.7270/Q2HT2QTR
					More data for this Ligand-Target Pair