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BDBM50007190 CHEMBL3237589

SMILES: CCn1c2ccccc2c2cc(Nc3ccnc(NCCCN4CCOCC4)n3)ccc12

InChI Key: InChIKey=AFTZZRFCMOAFCR-UHFFFAOYSA-N

Data: 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50007190
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 (Homo sapiens (Human))	BDBM50007190 (CHEMBL3237589) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assay				J Med Chem 57: 2953-62 (2014) Article DOI: 10.1021/jm401924s BindingDB Entry DOI: 10.7270/Q2D2204K
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 (Homo sapiens (Human))	BDBM50007190 (CHEMBL3237589) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Puerto Rico Curated by ChEMBL					Assay Description Inhibition of Vav2 binding to Rac1 G15A mutant in human MDA-MB-231 cells after 1 hr by pull down assay				Bioorg Med Chem 26: 884-890 (2018) Article DOI: 10.1016/j.bmc.2018.01.003 BindingDB Entry DOI: 10.7270/Q2319ZG5
University of Puerto Rico Curated by ChEMBL					More data for this Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 (Homo sapiens (Human))	BDBM50007190 (CHEMBL3237589) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Puerto Rico Curated by ChEMBL					Assay Description Inhibition of Rac1 in human MDA-MB-231 cells assessed as reduction in Rac-GTP level after 24 hrs by ELISA-based pull down assay				Bioorg Med Chem 26: 884-890 (2018) Article DOI: 10.1016/j.bmc.2018.01.003 BindingDB Entry DOI: 10.7270/Q2319ZG5
University of Puerto Rico Curated by ChEMBL					More data for this Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 (Homo sapiens (Human))	BDBM50007190 (CHEMBL3237589) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Puerto Rico Curated by ChEMBL					Assay Description Inhibition of Rac1 in human MDA-MB-435 cells assessed as reduction in Rac-GTP level after 24 hrs by ELISA-based pull down assay				Bioorg Med Chem 26: 884-890 (2018) Article DOI: 10.1016/j.bmc.2018.01.003 BindingDB Entry DOI: 10.7270/Q2319ZG5
University of Puerto Rico Curated by ChEMBL					More data for this Ligand-Target Pair