BDBM50007658 CHEMBL3233141

SMILES: CC[C@@H](CS(=O)(=O)C(C)(C)C)N1[C@@H]([C@H](O[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=NCNVGCDVSSOKED-UCXAEWMPSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50007658   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50007658 (CHEMBL3233141) Show SMILES CC[C@@H](CS(=O)(=O)C(C)(C)C)N1[C@@H]([C@H](O[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H33Cl2NO6S/c1-6-21(16-37(34,35)26(2,3)4)30-23(17-10-12-19(28)13-11-17)24(18-8-7-9-20(29)14-18)36-27(5,25(30)33)15-22(31)32/h7-14,21,23-24H,6,15-16H2,1-5H3,(H,31,32)/t21-,23+,24+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...				J Med Chem 57: 2472-88 (2014) Article DOI: 10.1021/jm401767k BindingDB Entry DOI: 10.7270/Q2C24XZZ
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50007658 (CHEMBL3233141) Show SMILES CC[C@@H](CS(=O)(=O)C(C)(C)C)N1[C@@H]([C@H](O[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H33Cl2NO6S/c1-6-21(16-37(34,35)26(2,3)4)30-23(17-10-12-19(28)13-11-17)24(18-8-7-9-20(29)14-18)36-27(5,25(30)33)15-22(31)32/h7-14,21,23-24H,6,15-16H2,1-5H3,(H,31,32)/t21-,23+,24+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...				J Med Chem 57: 2472-88 (2014) Article DOI: 10.1021/jm401767k BindingDB Entry DOI: 10.7270/Q2C24XZZ
					More data for this Ligand-Target Pair