BDBM50007772 CHEMBL3233782

SMILES: OC1CN(C\C=C\C(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3s2)C1

InChI Key: InChIKey=JKABMGXBBVXKDI-OWOJBTEDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50007772   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50007772 (CHEMBL3233782) Show SMILES OC1CN(C\C=C\C(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3s2)C1 Show InChI InChI=1S/C19H17ClFN5O2S/c20-14-6-11(3-4-15(14)21)24-18-13-7-17(29-19(13)23-10-22-18)25-16(28)2-1-5-26-8-12(27)9-26/h1-4,6-7,10,12,27H,5,8-9H2,(H,25,28)(H,22,23,24)/b2-1+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of wild type EGFR domain (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 substrate after 60 mins by ELI...				Bioorg Med Chem 22: 2366-78 (2014) Article DOI: 10.1016/j.bmc.2014.01.035 BindingDB Entry DOI: 10.7270/Q2QC051F
					More data for this Ligand-Target Pair