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SMILES: Fc1ccc(Nc2ncnc3sc(NC(=O)\C=C\CN4CCC(F)(F)C4)cc23)cc1Cl

InChI Key: InChIKey=XCWJDSNCBZCEQB-OWOJBTEDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50007773   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50007773
PNG
(CHEMBL3233783)
Show SMILES Fc1ccc(Nc2ncnc3sc(NC(=O)\C=C\CN4CCC(F)(F)C4)cc23)cc1Cl
Show InChI InChI=1S/C20H17ClF3N5OS/c21-14-8-12(3-4-15(14)22)27-18-13-9-17(31-19(13)26-11-25-18)28-16(30)2-1-6-29-7-5-20(23,24)10-29/h1-4,8-9,11H,5-7,10H2,(H,28,30)(H,25,26,27)/b2-1+
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Similars
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of wild type EGFR domain (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 substrate after 60 mins by ELI...

Bioorg Med Chem 22: 2366-78 (2014)


Article DOI: 10.1016/j.bmc.2014.01.035
BindingDB Entry DOI: 10.7270/Q2QC051F
More data for this
Ligand-Target Pair