BDBM50007786 CHEMBL3233794

SMILES: Fc1ccc(Nc2ncnc3sc(NC(=O)\C=C\CN4CC5(C4)CCOCC5)cc23)cc1Cl

InChI Key: InChIKey=SZLAQBNHGVKZED-OWOJBTEDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50007786   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50007786 (CHEMBL3233794) Show SMILES Fc1ccc(Nc2ncnc3sc(NC(=O)\C=C\CN4CC5(C4)CCOCC5)cc23)cc1Cl Show InChI InChI=1S/C23H23ClFN5O2S/c24-17-10-15(3-4-18(17)25)28-21-16-11-20(33-22(16)27-14-26-21)29-19(31)2-1-7-30-12-23(13-30)5-8-32-9-6-23/h1-4,10-11,14H,5-9,12-13H2,(H,29,31)(H,26,27,28)/b2-1+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of wild type EGFR domain (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 substrate after 60 mins by ELI...				Bioorg Med Chem 22: 2366-78 (2014) Article DOI: 10.1016/j.bmc.2014.01.035 BindingDB Entry DOI: 10.7270/Q2QC051F
					More data for this Ligand-Target Pair