BindingDB PrimarySearch

BDBM50008059 CHEBI:5292::GELDANAMYCIN

SMILES: CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O

InChI Key: InChIKey=QTQAWLPCGQOSGP-KSRBKZBZSA-N

Data: 29 IC50 5 Kd

PDB links: 10 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50008059
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Heat-shock protein 90 (Hsp90) (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	7.3	n/a
Shandong University					Assay Description Briefly, reaction mixes (100 �L) containing 20 mM HEPES (pH 7.3), 50 mM KCl, 2 mM DTT, 5 mM MgCl2, 20 mM Na2MoO4, 0.01% Triton X-100 with 0.1 mg/mL B...				Chem Biol Drug Des 85: 181-8 (2015) Article DOI: 10.1111/cbdd.12371 BindingDB Entry DOI: 10.7270/Q22B8WRB
Shandong University					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
South China Sea Institute of Oceanology Curated by ChEMBL					Assay Description Inhibition of HSP90alpha (unknown origin)				Bioorg Med Chem Lett 30: (2020)
South China Sea Institute of Oceanology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	714	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Binding affinity to N-terminal FLAG-tagged human recombinant HSP90alpha expressed in Escherichia coli BL21(DE3) by microscale thermophoresis assay				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of GM-BODIPY from human full length HSP90 alpha expressed in baculovirus-infected Sf9 cells after 16 hrs by fluorescence polarization as...				Bioorg Med Chem Lett 24: 2525-9 (2014) Article DOI: 10.1016/j.bmcl.2014.03.100 BindingDB Entry DOI: 10.7270/Q2QF8VDC
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of GA-FITC binding to human recombinant Hsp90alpha incubated for 5 hrs by fluorescence polarization assay				Eur J Med Chem 87: 346-63 (2014) Article DOI: 10.1016/j.ejmech.2014.09.078 BindingDB Entry DOI: 10.7270/Q2B27WWG
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90 (Oryctolagus cuniculus)	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
Tufts University Curated by ChEMBL					Assay Description Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assay				Bioorg Med Chem 22: 3989-93 (2014) Article DOI: 10.1016/j.bmc.2014.06.006 BindingDB Entry DOI: 10.7270/Q24F1SDM
Tufts University Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Tufts University Curated by ChEMBL					Assay Description Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly l...				Bioorg Med Chem 22: 3989-93 (2014) Article DOI: 10.1016/j.bmc.2014.06.006 BindingDB Entry DOI: 10.7270/Q24F1SDM
Tufts University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Displacement of GA-FITC from human recombinant HSP90alpha ATP-binding site by fluorescence polarization assay				Eur J Med Chem 85: 359-70 (2014) Article DOI: 10.1016/j.ejmech.2014.07.101 BindingDB Entry DOI: 10.7270/Q25M67CG
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Sloan-Kettering Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of steady-state expression of Raf-1 in MCF-7 breast cancer cells				Bioorg Med Chem Lett 9: 1233-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5Q0T
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Keimyung University Curated by ChEMBL					Assay Description Inhibition of fluorescein isothiocyanate labeled geldanamycin binding to N-terminal domain of full length human recombinant Hsp90alpha expressed in E...				Eur J Med Chem 124: 1069-1080 (2016) Article DOI: 10.1016/j.ejmech.2016.10.038 BindingDB Entry DOI: 10.7270/Q29G5PZZ
Keimyung University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Keimyung University Curated by ChEMBL					Assay Description Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...				Eur J Med Chem 143: 390-401 (2018) Article DOI: 10.1016/j.ejmech.2017.11.054 BindingDB Entry DOI: 10.7270/Q29C713M
Keimyung University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of geldanamycin-based probe binding to HSP90 (unknown origin) by fluorescence polarization assay				Bioorg Med Chem Lett 28: 1357-1362 (2018) Article DOI: 10.1016/j.bmcl.2018.03.009 BindingDB Entry DOI: 10.7270/Q2FB55KP
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of HSP90alpha (unknown origin)				Bioorg Med Chem Lett 28: 1357-1362 (2018) Article DOI: 10.1016/j.bmcl.2018.03.009 BindingDB Entry DOI: 10.7270/Q2FB55KP
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
Boston University Curated by ChEMBL					Assay Description Binding affinity to Heat Shock Protein 90 (unknown origin)				J Med Chem 62: 10005-10025 (2019) Article DOI: 10.1021/acs.jmedchem.8b01732
Boston University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article	n/a	n/a	272	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release by malachite green colorimetric me...				Citation and Details Article DOI: 10.1007/s00044-011-9557-9 BindingDB Entry DOI: 10.7270/Q2V127QS
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Bcr-Abl (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of imatinib-resistant BCR-ABL T315I mutant (unknown origin) expressed in mouse BA/F3 cells assessed as decrease in cell viability after 48...				J Med Chem 59: 5563-86 (2016) Article DOI: 10.1021/acs.jmedchem.5b01106
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Bcr-Abl (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of BCR-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as decrease in cell viability after 48 hrs by trypan blue exclusion as...				J Med Chem 59: 5563-86 (2016) Article DOI: 10.1021/acs.jmedchem.5b01106
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Bcr-Abl (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of imatinib-resistant BCR-ABL T315I mutant (unknown origin) expressed in mouse BA/F3 cells assessed as decrease in cell viability after 48...				J Med Chem 59: 5563-86 (2016) Article DOI: 10.1021/acs.jmedchem.5b01106
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Bcr-Abl (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of BCR-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as decrease in cell viability after 48 hrs by trypan blue exclusion as...				J Med Chem 59: 5563-86 (2016) Article DOI: 10.1021/acs.jmedchem.5b01106
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of Hsp90 in human SKBR3 cells				J Med Chem 59: 5563-86 (2016) Article DOI: 10.1021/acs.jmedchem.5b01106
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of Hsp90 in human SKBR3 cells				J Med Chem 59: 5563-86 (2016) Article DOI: 10.1021/acs.jmedchem.5b01106
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Peking Union Medical College & Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Displacement of fluorescent labelled-VER00051001 from N-terminal ATP-binding site of human recombinant HSP90A expressed in Escherichia coli measured ...				Bioorg Med Chem Lett 26: 4287-91 (2016) Article DOI: 10.1016/j.bmcl.2016.07.040
					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein 90, putative (Plasmodium falciparum 3D7)	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	169	n/a	n/a	n/a	n/a	n/a
Universit£ de Gen£ve Curated by ChEMBL					Assay Description Binding affinity to recombinant Plasmodium falciparum Hsp90 expressed in Escherichia coli BL21(DE3) pLysS by microscale thermophoresis assay				J Med Chem 59: 6344-52 (2016) Article DOI: 10.1021/acs.jmedchem.6b00591
Universit£ de Gen£ve Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a
Universit£ de Gen£ve Curated by ChEMBL					Assay Description Binding affinity to recombinant human Hsp90 beta expressed in Escherichia coli BL21(DE3) pLysS by microscale thermophoresis assay				J Med Chem 59: 6344-52 (2016) Article DOI: 10.1021/acs.jmedchem.6b00591
Universit£ de Gen£ve Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-beta (Homo sapiens (Human))	BDBM50008059 (CHEBI:5292 \| GELDANAMYCIN) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Binding affinity to N-terminal FLAG-tagged human recombinant HSP90beta expressed in Escherichia coli BL21(DE3) by microscale thermophoresis assay				J Med Chem 57: 2524-35 (2014) Article DOI: 10.1021/jm401801t BindingDB Entry DOI: 10.7270/Q2XW4MBD
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)