BDBM50008745 CHEMBL3236329
SMILES: FC(F)(F)Oc1cccc(c1)C(=O)NCc1noc(n1)-c1n(CCn2ccnc2)nc2ccccc12
InChI Key: InChIKey=IWCGRJRLSWGIIP-UHFFFAOYSA-N
Data: 24 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.8 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 3 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 3 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 3 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.6 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.6 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 assessed as tonic block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.8 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.8 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM50008745 (CHEMBL3236329) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assay | J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ | |||||||||||
More data for this Ligand-Target Pair |