BDBM50008746 CHEMBL3236343

SMILES: O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1

InChI Key: InChIKey=PYIJFQHNPPKBFX-UHFFFAOYSA-N

Data: 24 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50008746   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.8 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3) (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3) (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.3 (Nav1.3) (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4) (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4) (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4) (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.6 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.6 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 assessed as tonic block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.8 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.8 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair
Sodium channel alpha subunit (Homo sapiens (Human))	BDBM50008746 (CHEMBL3236343) Show SMILES O=C(NCc1noc(n1)-c1nn(CCn2ccnc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C22H19N7O2/c30-21(16-6-2-1-3-7-16)24-14-19-25-22(31-27-19)20-17-8-4-5-9-18(17)29(26-20)13-12-28-11-10-23-15-28/h1-11,15H,12-14H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University College London Curated by ChEMBL					Assay Description Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assay				J Med Chem 57: 2942-52 (2014) Article DOI: 10.1021/jm401881q BindingDB Entry DOI: 10.7270/Q2CZ38QJ
					More data for this Ligand-Target Pair