BDBM50008773 CHEMBL3236646

SMILES: Cc1cc(C[C@@]2(C)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C(C)(C)C)C3CC3)C2=O)c2ccc(Cl)cc2)c2cccc(Cl)c2)ncc1C(O)=O

InChI Key: InChIKey=FGEFVHVLJFIHGW-WZZDHPINSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50008773   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50008773 (CHEMBL3236646) Show SMILES Cc1cc(C[C@@]2(C)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C(C)(C)C)C3CC3)C2=O)c2ccc(Cl)cc2)c2cccc(Cl)c2)ncc1C(O)=O |r| Show InChI InChI=1S/C35H40Cl2N2O5S/c1-21-15-27(38-19-29(21)32(40)41)17-35(5)18-28(24-7-6-8-26(37)16-24)31(23-11-13-25(36)14-12-23)39(33(35)42)30(22-9-10-22)20-45(43,44)34(2,3)4/h6-8,11-16,19,22,28,30-31H,9-10,17-18,20H2,1-5H3,(H,40,41)/t28-,30-,31-,35+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...				J Med Chem 57: 2963-88 (2014) Article DOI: 10.1021/jm401911v BindingDB Entry DOI: 10.7270/Q2862J0J
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50008773 (CHEMBL3236646) Show SMILES Cc1cc(C[C@@]2(C)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C(C)(C)C)C3CC3)C2=O)c2ccc(Cl)cc2)c2cccc(Cl)c2)ncc1C(O)=O |r| Show InChI InChI=1S/C35H40Cl2N2O5S/c1-21-15-27(38-19-29(21)32(40)41)17-35(5)18-28(24-7-6-8-26(37)16-24)31(23-11-13-25(36)14-12-23)39(33(35)42)30(22-9-10-22)20-45(43,44)34(2,3)4/h6-8,11-16,19,22,28,30-31H,9-10,17-18,20H2,1-5H3,(H,40,41)/t28-,30-,31-,35+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...				J Med Chem 57: 2963-88 (2014) Article DOI: 10.1021/jm401911v BindingDB Entry DOI: 10.7270/Q2862J0J
					More data for this Ligand-Target Pair