BDBM50008936 (S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::9-aminocamptothecan::CHEMBL274070::cid_72402
SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc(N)c4cc3Cn1c2=O
InChI Key: InChIKey=FUXVKZWTXQUGMW-FQEVSTJZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hsf1 protein (Mus musculus) | BDBM50008936 ((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | n/a | >2.60E+5 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2P55KXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50008936 ((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | J Med Chem 36: 2689-700 (1993) BindingDB Entry DOI: 10.7270/Q2KP82RH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50008936 ((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 min | Bioorg Med Chem Lett 7: 847-850 (1997) Article DOI: 10.1016/S0960-894X(97)00105-4 BindingDB Entry DOI: 10.7270/Q2T43T3V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50008936 ((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested in vitro for inhibition of topoisomerase I. | Bioorg Med Chem Lett 6: 671-674 (1996) Article DOI: 10.1016/0960-894X(96)00083-2 BindingDB Entry DOI: 10.7270/Q2T153MM | |||||||||||
More data for this Ligand-Target Pair |