BDBM50009206 CHEMBL3233150

SMILES: Cn1c(CN2C(=O)CN(C2=O)c2ccc(OCc3ccncc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N

InChI Key: InChIKey=JZWSOYTZZLPQDL-NRFANRHFSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50009206   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (Homo sapiens (Human))	BDBM50009206 (CHEMBL3233150) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(OCc3ccncc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C31H32N10O5/c1-39-23(12-20-15-36-28(38-29(20)39)30(44)37-21(14-33)4-2-3-9-32)16-41-26(42)17-40(31(41)45)22-5-6-25(24(13-22)27(34)43)46-18-19-7-10-35-11-8-19/h5-8,10-13,15,21H,2-4,9,16-18,32H2,1H3,(H2,34,43)(H,37,44)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasmin using H-D-Val-Leu-LyspNA (S-2251) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50009206 (CHEMBL3233150) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(OCc3ccncc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C31H32N10O5/c1-39-23(12-20-15-36-28(38-29(20)39)30(44)37-21(14-33)4-2-3-9-32)16-41-26(42)17-40(31(41)45)22-5-6-25(24(13-22)27(34)43)46-18-19-7-10-35-11-8-19/h5-8,10-13,15,21H,2-4,9,16-18,32H2,1H3,(H2,34,43)(H,37,44)/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasma urokinase using Glu-Gly-Arg-pNA (S-2444) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50009206 (CHEMBL3233150) Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(OCc3ccncc3)c(c2)C(N)=O)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N |r| Show InChI InChI=1S/C31H32N10O5/c1-39-23(12-20-15-36-28(38-29(20)39)30(44)37-21(14-33)4-2-3-9-32)16-41-26(42)17-40(31(41)45)22-5-6-25(24(13-22)27(34)43)46-18-19-7-10-35-11-8-19/h5-8,10-13,15,21H,2-4,9,16-18,32H2,1H3,(H2,34,43)(H,37,44)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Hiroshima International University Curated by ChEMBL					Assay Description Inhibition of human plasma kallikerin using H-D-Phe-Pro-Arg-pNA (S-2302) peptide as substrate assessed as reduction of enzyme hydrolytic activity				Bioorg Med Chem 22: 2339-52 (2014) Article DOI: 10.1016/j.bmc.2014.02.002 BindingDB Entry DOI: 10.7270/Q2KH0PVJ
					More data for this Ligand-Target Pair