BindingDB PrimarySearch

BDBM50009366 CHEMBL3233842::US9346814, Cmpd No 1, Example 1

SMILES: FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1ccnc2ccccc12

InChI Key: InChIKey=PUOOCZVRHBHJRS-NSHDSACASA-N

Data: 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50009366
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast activation protein (FAP) (Mus musculus (Mouse))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	8.3	37
Universiteit Antwerp; Fox Chase Cancer Center US Patent					Assay Description Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...				US Patent US9346814 (2016) BindingDB Entry DOI: 10.7270/Q2W37V6D
Universiteit Antwerp; Fox Chase Cancer Center US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.25E+4	n/a	n/a	n/a	n/a	8.3	37
Universiteit Antwerp; Fox Chase Cancer Center US Patent					Assay Description Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...				US Patent US9346814 (2016) BindingDB Entry DOI: 10.7270/Q2W37V6D
Universiteit Antwerp; Fox Chase Cancer Center US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.3	37
Universiteit Antwerp; Fox Chase Cancer Center US Patent					Assay Description Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...				US Patent US9346814 (2016) BindingDB Entry DOI: 10.7270/Q2W37V6D
Universiteit Antwerp; Fox Chase Cancer Center US Patent					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.80E+3	n/a	n/a	n/a	n/a	8.3	37
Universiteit Antwerp; Fox Chase Cancer Center US Patent					Assay Description Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...				US Patent US9346814 (2016) BindingDB Entry DOI: 10.7270/Q2W37V6D
Universiteit Antwerp; Fox Chase Cancer Center US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometry				J Med Chem 57: 3053-74 (2014) Article DOI: 10.1021/jm500031w BindingDB Entry DOI: 10.7270/Q2P84DFW
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometry				J Med Chem 57: 3053-74 (2014) Article DOI: 10.1021/jm500031w BindingDB Entry DOI: 10.7270/Q2P84DFW
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast activation protein (FAP) (Mus musculus (Mouse))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometry				J Med Chem 57: 3053-74 (2014) Article DOI: 10.1021/jm500031w BindingDB Entry DOI: 10.7270/Q2P84DFW
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometry				J Med Chem 57: 3053-74 (2014) Article DOI: 10.1021/jm500031w BindingDB Entry DOI: 10.7270/Q2P84DFW
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Acyl-protein thioesterase 1/2 (Rattus norvegicus)	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Peking University First Hospital Curated by ChEMBL					Assay Description Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate measured upto 60 mins by fluorescence based assay				Bioorg Med Chem Lett 30: (2020)
Peking University First Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Acyl-protein thioesterase 1/2 (Rattus norvegicus)	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Peking University First Hospital Curated by ChEMBL					Assay Description Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assay				Bioorg Med Chem Lett 30: (2020)
Peking University First Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Acyl-protein thioesterase 1/2 (Rattus norvegicus)	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50009366 (CHEMBL3233842 \| US9346814, Cmpd No 1, Example 1) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.3	37
Universiteit Antwerp; Fox Chase Cancer Center US Patent					Assay Description Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...				US Patent US9346814 (2016) BindingDB Entry DOI: 10.7270/Q2W37V6D
Universiteit Antwerp; Fox Chase Cancer Center US Patent					More data for this Ligand-Target Pair