Found 15 hits for monomerid = 50009860 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 96: 7563-8 (1999)
Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4 |
More data for this Ligand-Target Pair | |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB
UniProtKB/SwissProt
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Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
| |
Am J Med 104: 413-21 (1998)
Article DOI: 10.1016/s0002-9343(98)00091-6 BindingDB Entry DOI: 10.7270/Q2F18X97 |
More data for this Ligand-Target Pair | |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 96: 7563-8 (1999)
Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 96: 7563-8 (1999)
Article DOI: 10.1073/pnas.96.13.7563 BindingDB Entry DOI: 10.7270/Q21G0JT4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
| |
Am J Med 104: 413-21 (1998)
Article DOI: 10.1016/s0002-9343(98)00091-6 BindingDB Entry DOI: 10.7270/Q2F18X97 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hormone-sensitive lipase (HSL)
(Rattus norvegicus (Rat)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay |
J Med Chem 51: 6478-94 (2008)
Article DOI: 10.1021/jm800718k BindingDB Entry DOI: 10.7270/Q23778KJ |
More data for this Ligand-Target Pair | |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article
| n/a | n/a | 2.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested in vitro for inhibition of human umbilical cord endothelial cells(ECV-304 cell line) Prostaglandin G/H synthase 2 at 10 microM |
Bioorg Med Chem Lett 6: 2281-2282 (1996)
Article DOI: 10.1016/0960-894X(96)00412-X BindingDB Entry DOI: 10.7270/Q2H1320K |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin E synthase/G/H synthase 2
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis |
ACS Med Chem Lett 6: 1086-90 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00286 BindingDB Entry DOI: 10.7270/Q2ZG6W79 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis |
ACS Med Chem Lett 6: 1086-90 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00286 BindingDB Entry DOI: 10.7270/Q2ZG6W79 |
More data for this Ligand-Target Pair | |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Horticulture and National Food Safety and Toxicology Center
Curated by ChEMBL
| Assay Description Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandin |
J Nat Prod 62: 294-6 (1999)
Article DOI: 10.1021/np980501m BindingDB Entry DOI: 10.7270/Q28G8KG8 |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase
(Rattus norvegicus) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate |
J Med Chem 40: 819-24 (1997)
Article DOI: 10.1021/jm9606150 BindingDB Entry DOI: 10.7270/Q2DF6Q9T |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase (cyclooxygenase)
(Ovis aries (Sheep)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB
KEGG
UniProtKB/SwissProt
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
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| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis |
ACS Med Chem Lett 6: 1086-90 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00286 BindingDB Entry DOI: 10.7270/Q2ZG6W79 |
More data for this Ligand-Target Pair | |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Patents
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| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition activity against recombinant human Prostaglandin G/H synthase 1 |
J Med Chem 40: 819-24 (1997)
Article DOI: 10.1021/jm9606150 BindingDB Entry DOI: 10.7270/Q2DF6Q9T |
More data for this Ligand-Target Pair | |
Cyclooxygenase-1 (COX-1)
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested in vitro for inhibition of human platelet Prostaglandin G/H synthase 1 at 10 microM |
Bioorg Med Chem Lett 6: 2281-2282 (1996)
Article DOI: 10.1016/0960-894X(96)00412-X BindingDB Entry DOI: 10.7270/Q2H1320K |
More data for this Ligand-Target Pair | |
Cyclooxygenase
(Homo sapiens (Human)) | BDBM50009860
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL KEGG MMDB PC cid PC sid PDB UniChem
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| MMDB PDB Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition activity against recombinant human Prostaglandin G/H synthase 2 |
J Med Chem 40: 819-24 (1997)
Article DOI: 10.1021/jm9606150 BindingDB Entry DOI: 10.7270/Q2DF6Q9T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |