BDBM50009941 1-Phenyl-tetrahydro-pyridazin-3-one::CHEMBL30110

SMILES: O=C1CCCN(N1)c1ccccc1

InChI Key: InChIKey=XHYBFCBDMIPDON-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50009941   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated				Bioorg Med Chem Lett 2: 1353-1356 (1992) Article DOI: 10.1016/S0960-894X(00)80511-9 BindingDB Entry DOI: 10.7270/Q2H41RC2
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluated				Bioorg Med Chem Lett 2: 1353-1356 (1992) Article DOI: 10.1016/S0960-894X(00)80511-9 BindingDB Entry DOI: 10.7270/Q2H41RC2
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Sterling Research Group Curated by ChEMBL					Assay Description In vitro inhibition of rat 5-Lipoxygenase				J Med Chem 34: 1560-70 (1991) BindingDB Entry DOI: 10.7270/Q2RV0MPG
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation				J Med Chem 39: 3938-50 (1996) Article DOI: 10.1021/jm960372b BindingDB Entry DOI: 10.7270/Q2GQ6WWW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluated				Bioorg Med Chem Lett 2: 1353-1356 (1992) Article DOI: 10.1016/S0960-894X(00)80511-9 BindingDB Entry DOI: 10.7270/Q2H41RC2
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro 5-lipoxygenase inhibitory activity of the compound against calcium ionophore (A23187) induced LTB4 formation in rat polymorphonuclear leukoc...				J Med Chem 39: 3938-50 (1996) Article DOI: 10.1021/jm960372b BindingDB Entry DOI: 10.7270/Q2GQ6WWW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human polymorphonuclear leukocytes.				J Med Chem 39: 3938-50 (1996) Article DOI: 10.1021/jm960372b BindingDB Entry DOI: 10.7270/Q2GQ6WWW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against 5-lipoxygenase.				Bioorg Med Chem Lett 2: 1357-1360 (1992) Article DOI: 10.1016/S0960-894X(00)80512-0 BindingDB Entry DOI: 10.7270/Q2CC10M8
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against intact rat PMNL, LTB4 5-lipoxygenase was evaluated				Bioorg Med Chem Lett 2: 1353-1356 (1992) Article DOI: 10.1016/S0960-894X(00)80511-9 BindingDB Entry DOI: 10.7270/Q2H41RC2
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50009941 (1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110) Show SMILES O=C1CCCN(N1)c1ccccc1 Show InChI InChI=1S/C10H12N2O/c13-10-7-4-8-12(11-10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro 5-lipoxygenase inhibitory activity of the compound against calcium ionophore (A23187) induced LTB4 formation in human whole blood				J Med Chem 39: 3938-50 (1996) Article DOI: 10.1021/jm960372b BindingDB Entry DOI: 10.7270/Q2GQ6WWW
					More data for this Ligand-Target Pair