BDBM50010292 8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-{2-[4-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-phenyl]-ethyl}-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL92649
SMILES: [O-][N+](=O)c1ccc(Nc2ccc(CCN3CN(c4ccccc4)C4(CCN(CCCC(=O)c5ccc(F)cc5)CC4)C3=O)cc2)c2[n-][o+]nc12
InChI Key: InChIKey=AYDICYGRWUFLHA-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010292 (8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-{2-[4-(7-nit...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals Inc. Curated by ChEMBL | Assay Description Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkey | J Med Chem 34: 3235-41 (1991) BindingDB Entry DOI: 10.7270/Q2KS6S5V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50010292 (8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-{2-[4-(7-nit...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals Inc. Curated by ChEMBL | Assay Description Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey | J Med Chem 34: 3235-41 (1991) BindingDB Entry DOI: 10.7270/Q2KS6S5V | |||||||||||
More data for this Ligand-Target Pair |