BDBM50010300 (RS)3',6'-dihydroxy-5-[4-{2-[5-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl(propyl)amino]ethyl}anilino(thioxo)methylamino]spiro[1,3-dihydroisobenzofuran-1,9'-(9'H-xanthene)]-3-one::CHEMBL320526
SMILES: CCCN(CCc1ccc(NC(=S)Nc2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc23)cc1)C1CCc2c(O)cccc2C1
InChI Key: InChIKey=GUYDMNDOMIQYML-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50010300 ((RS)3',6'-dihydroxy-5-[4-{2-[5-hydroxy-1,2,3,4-tet...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals Inc. Curated by ChEMBL | Assay Description Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkey | J Med Chem 34: 3235-41 (1991) BindingDB Entry DOI: 10.7270/Q2KS6S5V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50010300 ((RS)3',6'-dihydroxy-5-[4-{2-[5-hydroxy-1,2,3,4-tet...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals Inc. Curated by ChEMBL | Assay Description Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey | J Med Chem 34: 3235-41 (1991) BindingDB Entry DOI: 10.7270/Q2KS6S5V | |||||||||||
More data for this Ligand-Target Pair |