BindingDB PrimarySearch

BDBM50010361 (S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid::1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid::1-(4-amino-2-methylbenzyl)-5-diphenylcarbamoyl-(6S)-4,5,6,7-tetrahydro-1H-imidazo[5,4-c]pyridine-6-carboxylic acid::CHEMBL292277::EXP655::PD 123177::PD-123177

SMILES: Cc1cc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c2ccccc2)c2ccccc2)ccc1N

InChI Key: InChIKey=KLVDUSUYBDMJKR-SANMLTNESA-N

Data: 4 KI 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50010361
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Angiotensin II AT2 (RAT)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	14.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Pharmaceuticals Limited Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1042-53 (1995) BindingDB Entry DOI: 10.7270/Q20G3HN9
					More data for this Ligand-Target Pair
Angiotensin II AT2 (RAT)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Pharmaceuticals Limited Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1042-53 (1995) BindingDB Entry DOI: 10.7270/Q20G3HN9
					More data for this Ligand-Target Pair
Angiotensin IV (BOVINE)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington State University Curated by PDSP K_i Database									J Pharmacol Exp Ther 291: 1242-9 (1999) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2377783
Washington State University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Angiotensin IV (BOVINE)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington State University Curated by PDSP K_i Database									J Pharmacol Exp Ther 291: 1242-9 (1999) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2377783
Washington State University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Angiotensin II receptor (RAT)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Warner Lambert Company Curated by ChEMBL					Assay Description Binding affinity against Angiotensin II receptor, from rat adrenal gland				J Med Chem 34: 3248-60 (1991) BindingDB Entry DOI: 10.7270/Q24X5B06
Warner Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1 (RAT)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Warner Lambert Company Curated by ChEMBL					Assay Description Binding affinity against Angiotensin II receptor, from rat brain				J Med Chem 34: 3248-60 (1991) BindingDB Entry DOI: 10.7270/Q24X5B06
Warner Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin II receptor (Homo sapiens (Human))	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibition of Angiotensin II receptor, type 1				J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299
DuPont Merck Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin II receptor (Homo sapiens (Human))	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibition of Angiotensin II receptor, type 2				J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299
DuPont Merck Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1 (RAT)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Co. Curated by ChEMBL					Assay Description Binding affinity towards Angiotensin II receptor, type 1 in rat isolated adrenal cortical microsomes				J Med Chem 36: 3985-92 (1994) BindingDB Entry DOI: 10.7270/Q2CC0ZQT
DuPont Merck Pharmaceutical Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin II AT2 (RAT)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Co. Curated by ChEMBL					Assay Description Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes				J Med Chem 36: 3985-92 (1994) BindingDB Entry DOI: 10.7270/Q2CC0ZQT
DuPont Merck Pharmaceutical Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin II AT2 (RAT)	BDBM50010361 ((S)-1-(4-Amino-3-methyl-benzyl)-5-diphenylacetyl-4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay				Bioorg Med Chem Lett 3: 2023-2028 (1993) Article DOI: 10.1016/S0960-894X(01)81007-6 BindingDB Entry DOI: 10.7270/Q26973GR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair